3BQM

LFA-1 I domain bound to inhibitors

Summary for 3BQM
Related3BQN
DescriptorIntegrin alpha-L, 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline (3 entities in total)
Functional Keywordslfa-1 i domain, leukocyte function associated antigen-1, alternative splicing, calcium, cell adhesion, glycoprotein, integrin, magnesium, membrane, polymorphism, receptor, transmembrane
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein: P20701
Total number of polymer chains2
Total formula weight42594.59
Authors
Silvian, L.F. (deposition date: 2007-12-20, release date: 2008-08-19, Last modification date: 2011-07-13)
Primary citationChin, D.,Friedman, J.E.,Guckian, K.M.,Lin, E.Y.,Scott, D.M.,Silvian, L.
Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors
Bioorg.Med.Chem.Lett., 18:5249-5251, 2008
PubMed: 18778938
DOI: 110.1016/j.bmcl.2008.08.061
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation
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178938

PDB entries from 2021-06-16