Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1XDG

X-ray structure of LFA-1 I-domain in complex with LFA878 at 2.1A resolution

Summary for 1XDG
Entry DOI10.2210/pdb1xdg/pdb
Related1XDD
DescriptorIntegrin alpha-L, MAGNESIUM ION, (1S,3R,8AS)-8-(2-{(4S,6S)-3-(4-HYDROXY-3-METHOXYBENZYL)-4-[2-(METHYLAMINO)-2-OXOETHYL]-2-OXO-1,3-OXAZINAN-6-YL}ETHYL)-3 ,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL (2R)-2-METHYLBUTANOATE, ... (4 entities in total)
Functional Keywordsrossman-fold, i-domain, immune system
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P20701
Total number of polymer chains2
Total formula weight44093.24
Authors
Weitz-Schmidt, G.,Welzenbach, K.,Dawson, J.,Kallen, J. (deposition date: 2004-09-06, release date: 2004-09-21, Last modification date: 2023-10-25)
Primary citationWeitz-Schmidt, G.,Welzenbach, K.,Dawson, J.,Kallen, J.
Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo
J.Biol.Chem., 279:46764-46771, 2004
Cited by
PubMed: 15304496
DOI: 10.1074/jbc.M407951200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon