1XDG
X-ray structure of LFA-1 I-domain in complex with LFA878 at 2.1A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrin alpha-L | polymer | 188 | 21425.6 | 2 | UniProt (P20701) Pfam (PF00092) | Homo sapiens (human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function associated molecule 1, alpha chain, CD11a, alphaLbeta2, CD11a/CD18 |
| 2 | C, E (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, F (A, B) | (1S,3R,8AS)-8-(2-{(4S,6S)-3-(4-HYDROXY-3-METHOXYBENZYL)-4-[2-(METHYLAMINO)-2-OXOETHYL]-2-OXO-1,3-OXAZINAN-6-YL}ETHYL)-3 ,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL (2R)-2-METHYLBUTANOATE | non-polymer | 596.8 | 2 | Chemie (AB8) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A, B: 127 - 311 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | cloning artifact |
| Ala 125 | - | cloning artifact |
| Ser 126 | - | cloning artifact |
| Trp 189 | Arg 214 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42851.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1242.1 | |
| All* | Total formula weight | 44093.2 |
