3QA3

Crystal Structure of A-domain in complex with antibody

Summary for 3QA3

• Entry DOI: 10.2210/pdb3qa3/pdb
• Related: 3Q3G
• Descriptor: Antibody Light chain, Antibody Heavy chain, Integrin alpha-M, ... (7 entities in total)
• Functional Keywords: immune system- cell adhesion complex, immune system/ cell adhesion
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P11215
• Total number of polymer chains: 12
• Total formula weight: 282011.89

Authors

Mahalingam, B.,Xiong, J.P.,Arnaout, M.A. (deposition date: 2011-01-10, release date: 2011-11-30, Last modification date: 2023-09-13)

• Primary citation: Mahalingam, B.,Ajroud, K.,Alonso, J.L.,Anand, S.,Adair, B.D.,Horenstein, A.L.,Malavasi, F.,Xiong, J.P.,Arnaout, M.A.; Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design.; J.Immunol., 187:6393-6401, 2011; PubMed: 22095715; DOI: 10.4049/jimmunol.1102394

Experimental method

X-RAY DIFFRACTION (3 Å)