1XDD

X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution

Summary for 1XDD

• Entry DOI: 10.2210/pdb1xdd/pdb
• Related: 1XDG
• Descriptor: Integrin alpha-L, MAGNESIUM ION, 8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2-METHYLBUTANOATE, ... (4 entities in total)
• Functional Keywords: rossmann fold, i-domain, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P20701
• Total number of polymer chains: 2
• Total formula weight: 44107.31

Authors

Weitz-Schmidt, G.,Welzenbach, K.,Dawson, J.,Kallen, J. (deposition date: 2004-09-06, release date: 2004-09-21, Last modification date: 2023-10-25)

• Primary citation: Weitz-Schmidt, G.,Welzenbach, K.,Dawson, J.,Kallen, J.; Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo; J.Biol.Chem., 279:46764-46771, 2004; PubMed: 15304496; DOI: 10.1074/jbc.M407951200

Experimental method

X-RAY DIFFRACTION (2.2 Å)