1XDD
X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrin alpha-L | polymer | 188 | 21425.6 | 2 | UniProt (P20701) Pfam (PF00092) | Homo sapiens (human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function associated molecule 1, alpha chain, CD11a, alphaLbeta2, CD11a/CD18 |
| 2 | C, E (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, F (A, B) | 8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2-METHYLBUTANOATE | non-polymer | 603.8 | 2 | Chemie (AAY) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A, B: 127 - 311 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | cloning artifact |
| Ala 125 | - | cloning artifact |
| Ser 126 | - | cloning artifact |
| Trp 189 | Arg 214 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42851.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1256.2 | |
| All* | Total formula weight | 44107.3 |
