PDB: 6519 resultsInfo pagesStatus searchChemie searchBIRD

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2RAR	X-ray Crystallographic Structures Show Conservation of a Trigonal-Bipyramidal Intermediate in a Phosphoryl-transfer Superfamily. Descriptor: MAGNESIUM ION, Putative uncharacterized protein, oxido(dioxo)vanadium Authors: Lu, Z, Dunaway-Mariano, D, Allen, K.N. Deposit date: 2007-09-17 Release date: 2008-04-22 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.52 Å) Cite: The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state. Proc.Natl.Acad.Sci.Usa, 105, 2008
2REF	Crystal structure of the loading GNATL domain of CurA from Lyngbya majuscula soaked with malonyl-CoA Descriptor: ACETYL COENZYME *A, CurA Authors: Geders, T.W, Smith, J.L. Deposit date: 2007-09-26 Release date: 2007-11-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.75 Å) Cite: GNAT-like strategy for polyketide chain initiation. Science, 318, 2007
4K30	Structure of the N-acetyltransferase domain of human N-acetylglutamate synthase Descriptor: N-ACETYL-L-GLUTAMATE, N-acetylglutamate synthase, mitochondrial Authors: Shi, D, Zhao, G, Jin, Z, Allewell, N.M, Tuchman, M. Deposit date: 2013-04-10 Release date: 2013-08-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.103 Å) Cite: Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. Plos One, 8, 2013
5ZQZ	Structure of human mitochondrial trifunctional protein, tetramer Descriptor: Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta Authors: Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. Deposit date: 2018-04-20 Release date: 2018-06-20 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Cryo-EM structure of human mitochondrial trifunctional protein Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1HZW	CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Almog, R, Waddling, C.A, Maley, F, Maley, G.F, Van Roey, P. Deposit date: 2001-01-26 Release date: 2001-05-09 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Protein Sci., 10, 2001
1I00	CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE, TERNARY COMPLEX WITH DUMP AND TOMUDEX Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX Authors: Almog, R.A, Waddling, C.A, Maley, F, Maley, G.F, Van Roey, P. Deposit date: 2001-01-27 Release date: 2001-05-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Protein Sci., 10, 2001
2R7H	CRYSTAL STRUCTURE OF A putative acetyltransferase of the GNAT family (DDE_3044) FROM DESULFOVIBRIO DESULFURICANS SUBSP. AT 1.85 A RESOLUTION Descriptor: 2-ETHOXYETHANOL, Putative D-alanine N-acetyltransferase of GNAT family Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2007-09-07 Release date: 2007-09-25 Last modified: 2023-01-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of putative D-alanine N-acetyltransferase of GNAT family (YP_389533.1) from Desulfovibrio desulfuricans G20 at 1.85 A resolution To be published
4K8T	Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with ethyl 3,4-diaminobenzoate Descriptor: ADENOSINE, DIMETHYL SULFOXIDE, POTASSIUM ION, ... Authors: Malashkevich, V.N, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Khafizov, K, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) Deposit date: 2013-04-18 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with ethyl 3,4-diaminobenzoate To be Published
2Z87	Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GalNAc and UDP Descriptor: Chondroitin synthase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... Authors: Osawa, T, Sugiura, N, Shimada, H, Hirooka, R, Tsuji, A, Kimura, M, Kimata, K, Kakuta, Y. Deposit date: 2007-09-03 Release date: 2008-09-16 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of chondroitin polymerase from Escherichia coli K4. Biochem. Biophys. Res. Commun., 378, 2009
2R82	Pyruvate phosphate dikinase (PPDK) triple mutant R219E/E271R/S262D adapts a second conformational state Descriptor: Pyruvate, phosphate dikinase, SULFATE ION Authors: Lim, K, Read, R.J, Chen, C.C, Herzberg, O. Deposit date: 2007-09-10 Release date: 2008-01-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Swiveling domain mechanism in pyruvate phosphate dikinase. Biochemistry, 46, 2007
3IHI	Crystal structure of mouse thymidylate synthase Descriptor: SULFATE ION, Thymidylate synthase Authors: Dowiercial, A, Jarmula, A, Rypniewski, W.R, Sokolowska, M, Fraczyk, T, Ciesla, J, Rode, W. Deposit date: 2009-07-30 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme Struct Chem, 2016
4KAM	X-ray crystal structure of O-acetylhomoserine sulfhydrylase MetC from Mycobacterium marinum ATCC BAA-535 / M Descriptor: O-acetylhomoserine sulfhydrylase MetC, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-04-22 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
2R8V	Native structure of N-acetylglutamate synthase from Neisseria gonorrhoeae Descriptor: ACETYL COENZYME *A, Putative acetylglutamate synthase Authors: Shi, D, Sagar, V, Jin, Z, Yu, X, Caldovic, L, Morizono, H, Allewell, N.M, Tuchman, M. Deposit date: 2007-09-11 Release date: 2008-01-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of N-acetyl-L-glutamate synthase from Neisseria gonorrhoeae provides insights into mechanisms of catalysis and regulation. J.Biol.Chem., 283, 2008
5ZZU	Crystal structure of the C-terminal periplasmic domain of EcEptC from Escherichia coli- complex with Zn Descriptor: Phosphoethanolamine transferase EptC, ZINC ION Authors: Zhao, Y.Q, Cheng, W, Gu, Y.J. Deposit date: 2018-06-04 Release date: 2019-06-05 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and mechanistic insights into polymyxin resistance mediated by EptC originating from Escherichia coli To Be Published
1M15	Transition state structure of arginine kinase Descriptor: ADENOSINE-5'-DIPHOSPHATE, ARGININE, MAGNESIUM ION, ... Authors: Yousef, M.S, Fabiola, F, Gattis, J.L, Somasundaram, T, Chapman, M.S. Deposit date: 2002-06-17 Release date: 2002-12-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Refinement of the arginine kinase transition-state analogue complex at 1.2 A resolution: mechanistic insights. Acta Crystallogr.,Sect.D, 58, 2002
4KPW	Crystal structure of His-tagged human thymidylate synthase R175A mutant Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase Authors: Pozzi, C, Mangani, S. Deposit date: 2013-05-14 Release date: 2014-05-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015
4KQ5	Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate Descriptor: 1,2-ETHANEDIOL, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... Authors: Barnett, B.L, Tsoumpra, M.K, Muniz, J.R.C. Deposit date: 2013-05-14 Release date: 2014-04-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate To be Published
1M3K	biosynthetic thiolase, inactive C89A mutant Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION Authors: Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K. Deposit date: 2002-06-28 Release date: 2002-11-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes Biochemistry, 41, 2002
3IQI	Structure of O-Acetylserine Sulfhydrylase in Complex with Peptide MNENI Descriptor: Cysteine synthase, MNENI Authors: Roderick, S.L. Deposit date: 2009-08-20 Release date: 2009-11-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Design of o-acetylserine sulfhydrylase inhibitors by mimicking nature. J.Med.Chem., 53, 2010
1I0E	CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE Descriptor: CREATINE KINASE,M CHAIN Authors: Shen, Y.-Q, Tang, L, Zhou, H.-M, Lin, Z.-J. Deposit date: 2001-01-29 Release date: 2003-04-01 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structure of human muscle creatine kinase. Acta Crystallogr.,Sect.D, 57, 2001
1S2V	Crystal structure of phosphoenolpyruvate mutase complexed with Mg(II) Descriptor: MAGNESIUM ION, Phosphoenolpyruvate phosphomutase Authors: Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O. Deposit date: 2004-01-11 Release date: 2004-05-04 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Conformational Flexibility of PEP Mutase Biochemistry, 43, 2004
4G2O	Human Thymidylate Synthase M190K with bound Purpurogallin Descriptor: 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one, SULFATE ION, Thymidylate synthase Authors: Celeste, L.R, Lebioda, L. Deposit date: 2012-07-12 Release date: 2013-07-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Oxidation of Cysteine 195 of Huyman Thymidylate Synthase by Purpurogallin To be Published
4G6W	Human Thymidylate Synthase M190K with bound 4-Bromobenzene-1,2,3-triol Descriptor: 4-bromobenzene-1,2,3-triol, SULFATE ION, Thymidylate synthase Authors: Celeste, L.R, Lebioda, L. Deposit date: 2012-07-19 Release date: 2013-07-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Oxidation of Cysteine 195 of Huyman Thymidylate Synthase by Purpurogallin To be Published, 2012
2RJT	Crystal Structure Analysis of a Surface Entropy Reduction Mutant of S. pneumoniae FabF Descriptor: Beta-ketoacyl-ACP synthase II Authors: Soisson, S.M, Parthasarathy, G, Becker, J. Deposit date: 2007-10-15 Release date: 2008-01-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae. Acta Crystallogr.,Sect.D, 64, 2008
1I12	CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE GNA1 COMPLEXED WITH ACCOA Descriptor: ACETYL COENZYME *A, GLUCOSAMINE-PHOSPHATE N-ACETYLTRANSFERASE, IMIDAZOLE Authors: Peneff, C, Mengin-Lecreulx, D, Bourne, Y. Deposit date: 2001-01-30 Release date: 2001-05-16 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase. J.Biol.Chem., 276, 2001

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