4KPW
Crystal structure of His-tagged human thymidylate synthase R175A mutant
Summary for 4KPW
Entry DOI | 10.2210/pdb4kpw/pdb |
Related | 3N5E 3N5G |
Descriptor | Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | interface hot spot, transferase, methyltransferase, nucleotide biosynthesis |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P04818 |
Total number of polymer chains | 1 |
Total formula weight | 37831.17 |
Authors | Pozzi, C.,Mangani, S. (deposition date: 2013-05-14, release date: 2014-05-14, Last modification date: 2023-09-20) |
Primary citation | Salo-Ahen, O.M.,Tochowicz, A.,Pozzi, C.,Cardinale, D.,Ferrari, S.,Boum, Y.,Mangani, S.,Stroud, R.M.,Saxena, P.,Myllykallio, H.,Costi, M.P.,Ponterini, G.,Wade, R.C. Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58:3572-3581, 2015 Cited by PubMed: 25798950DOI: 10.1021/acs.jmedchem.5b00137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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