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4KQ5

Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate

Summary for 4KQ5
Entry DOI10.2210/pdb4kq5/pdb
Related4KFA 4KPD 4KPJ 4KQS 4KQU
DescriptorFarnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID, ... (5 entities in total)
Functional Keywordsisoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, dimethylallyl pyrophosphate, isoprenoid pathway, cholesterol synthesis, bisphosphonates
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P14324
Total number of polymer chains1
Total formula weight43459.96
Authors
Barnett, B.L.,Tsoumpra, M.K.,Muniz, J.R.C. (deposition date: 2013-05-14, release date: 2014-04-30, Last modification date: 2023-09-20)
Primary citationTsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.,Kavanagh, K.L.,Evdokimov, A.G.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E.
Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate
To be Published,
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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