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6BVA
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BU of 6bva by Molmil
Ubiquitin Variant (UbV.Fl10.1) bound to a human Skp1-Fbl10 fragment complex.
Descriptor: Lysine-specific demethylase 2B, Polyubiquitin-B, S-phase kinase-associated protein 1
Authors:Manczyk, N, Sicheri, F.
Deposit date:2017-12-12
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Structure, 26, 2018
5CVN
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BU of 5cvn by Molmil
WDR48 (2-580):USP46~ubiquitin ternary complex
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ...
Authors:Harris, S.F, Yin, J.
Deposit date:2015-07-27
Release date:2015-10-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.36 Å)
Cite:Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
6BYH
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BU of 6byh by Molmil
Ubiquitin Variant (UbV.Fl11.1) bound to a human Skp1-Fbl11 fragment complex.
Descriptor: Lysine-specific demethylase 2A, Polyubiquitin-B, S-phase kinase-associated protein 1
Authors:Manczyk, N, Sicheri, F.
Deposit date:2017-12-20
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Structure, 26, 2018
5CVO
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BU of 5cvo by Molmil
WDR48:USP46~ubiquitin ternary complex
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ...
Authors:Harris, S.F, Yin, J.
Deposit date:2015-07-27
Release date:2015-10-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.885 Å)
Cite:Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
6FGE
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BU of 6fge by Molmil
Crystal structure of human ZUFSP/ZUP1 in complex with ubiquitin
Descriptor: ACETATE ION, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kwasna, D, Abdul Rehman, S.A, Kulathu, Y.
Deposit date:2018-01-10
Release date:2018-04-04
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Mol. Cell, 70, 2018
7KHH
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BU of 7khh by Molmil
Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxamide)
Descriptor: Bromodomain-containing protein 4, Elongin-B, Elongin-C, ...
Authors:Murray, J.M.
Deposit date:2020-10-21
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
J.Med.Chem., 64, 2021
4ZFR
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BU of 4zfr by Molmil
Catalytic domain of Sst2 F403A mutant bound to ubiquitin
Descriptor: 1,2-ETHANEDIOL, AMSH-like protease sst2, ZINC ION, ...
Authors:Shrestha, R.K.
Deposit date:2015-04-21
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure of Catalytic domain of Sst2 F403A mutant bound to ubiquitin at 1.7 Angstroms
To Be Published
7M3Q
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BU of 7m3q by Molmil
Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, ...
Authors:Chowdhury, A, Singer, A.U, Ogunjimi, A.A, Teyra, J, Zhang, W, Sicheri, F, Sidhu, S.S.
Deposit date:2021-03-18
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
To be published
4ZFT
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BU of 4zft by Molmil
Catalytic domain of Sst2 F403W mutant bound to ubiquitin
Descriptor: 1,2-ETHANEDIOL, AMSH-like protease sst2, Polyubiquitin-B, ...
Authors:Bueno, A.N.
Deposit date:2015-04-21
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Structure of the catalytic domain of Sst2 mutant F403W bound to ubiquitin at 2.3 Angstroms
To Be Published
7LTO
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BU of 7lto by Molmil
Nse5-6 complex
Descriptor: Non-structural maintenance of chromosome element 5, Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera
Authors:Yu, Y, Li, S.B, Zheng, S, Tangy, S, Koyi, C, Wan, B.B, Kung, H.H, Andrej, S, Alex, K, Patel, D.J, Zhao, X.L.
Deposit date:2021-02-19
Release date:2021-05-19
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MC9
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BU of 7mc9 by Molmil
X-RAY STRUCTURE OF PEDV PAPAIN-LIKE PROTEASE 2 bound to UB-PA
Descriptor: 3C-like proteinase, Ubiquitin, ZINC ION, ...
Authors:Durie, I.A, Dzimianski, J.V, Daczkowski, C.M, Pegan, S.D.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.099 Å)
Cite:Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin
Acta Cryst. D, 77, 2021
7MIC
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BU of 7mic by Molmil
Maize rayado fino virus protease in complex with Ubiquitin
Descriptor: 3-AMINOPROPANE, GLYCEROL, RNA replication protein, ...
Authors:Patel, A, Mark, B.L.
Deposit date:2021-04-16
Release date:2021-07-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase.
J.Biol.Chem., 297, 2021
5AF6
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BU of 5af6 by Molmil
Structure of Lys33-linked diUb bound to Trabid NZF1
Descriptor: TRABID, UBIQUITIN, ZINC ION
Authors:Michel, M.A, Elliott, P.R, Swatek, K.N, Simicek, M, Pruneda, J.N, Wagstaff, J.L, Freund, S.M.V, Komander, D.
Deposit date:2015-01-19
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin.
Mol.Cell, 58, 2015
7NPI
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BU of 7npi by Molmil
Crystal structure of Mindy2 (C266A) in complex with Lys48-linked penta-ubiquitin (K48-Ub5)
Descriptor: CHLORIDE ION, Polyubiquitin-C, SODIUM ION, ...
Authors:Lange, S.M, Armstrong, L.A, Kulathu, Y.
Deposit date:2021-02-26
Release date:2021-09-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021
4ZYN
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BU of 4zyn by Molmil
Crystal Structure of Parkin E3 ubiquitin ligase (linker deletion; delta 86-130)
Descriptor: E3 ubiquitin-protein ligase parkin, SULFATE ION, ZINC ION
Authors:Lilov, A, Sauve, V, Trempe, J.F, Rodionov, D, Wang, J, Gehring, K.
Deposit date:2015-05-21
Release date:2015-08-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:A Ubl/ubiquitin switch in the activation of Parkin.
Embo J., 34, 2015
5B83
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BU of 5b83 by Molmil
Crystal structure of Optineurin UBAN in complex with linear ubiquitin
Descriptor: Optineurin, tetra ubiquitin
Authors:Ishii, R, Nureki, O.
Deposit date:2016-06-12
Release date:2016-09-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.694 Å)
Cite:Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
Nat Commun, 7, 2016
4I6L
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BU of 4i6l by Molmil
Crystal structure of OTUB1 in complex with ubiquitin variant
Descriptor: Ubiquitin, Ubiquitin thioesterase OTUB1
Authors:Juang, Y.C, Sicheri, F.
Deposit date:2012-11-29
Release date:2013-01-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.488 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3L0W
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BU of 3l0w by Molmil
Structure of split monoubiquitinated PCNA with ubiquitin in position two
Descriptor: Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen
Authors:Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T.
Deposit date:2009-12-10
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange.
Nat.Struct.Mol.Biol., 17, 2010
3L10
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BU of 3l10 by Molmil
Structure of split monoubiquitinated PCNA with ubiquitin in position one
Descriptor: Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen
Authors:Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T.
Deposit date:2009-12-10
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange.
Nat.Struct.Mol.Biol., 17, 2010
4II3
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BU of 4ii3 by Molmil
Crystal structure of S. pombe Ubiquitin activating enzyme 1 (Uba1) in complex with ubiquitin and ATP/Mg
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ...
Authors:Olsen, S.K, Lima, C.D.
Deposit date:2012-12-19
Release date:2013-02-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Mol.Cell, 49, 2013
3LDZ
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BU of 3ldz by Molmil
Crystal structure of human STAM1 VHS domain in complex with ubiquitin
Descriptor: Signal transducing adapter molecule 1, Ubiquitin
Authors:Ren, X, Hurley, J.H.
Deposit date:2010-01-13
Release date:2010-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo.
Embo J., 29, 2010
4IUM
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BU of 4ium by Molmil
Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin
Descriptor: GLYCEROL, Ubiquitin, ZINC ION, ...
Authors:Bailey-Elkin, B.A, James, T.W, Mark, B.L.
Deposit date:2013-01-21
Release date:2013-02-13
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JQW
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BU of 4jqw by Molmil
Crystal Structure of a Complex of NOD1 CARD and Ubiquitin
Descriptor: Nucleotide-binding oligomerization domain-containing protein 1, PHOSPHATE ION, Polyubiquitin-C
Authors:Ver Heul, A.M, Gakhar, L, Piper, R.C, Ramaswamy, S.
Deposit date:2013-03-20
Release date:2014-03-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a complex of NOD1 CARD and ubiquitin
Plos One, 9, 2014
5HPK
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BU of 5hpk by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1
Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1
Authors:Wu, K.-P, Mukherjee, M, Mercredi, P.Y, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
4K1R
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BU of 4k1r by Molmil
Crystal structure of Schizosaccharomyces pombe sst2 catalytic domain and Ubiquitin
Descriptor: 1,2-ETHANEDIOL, AMSH-like protease sst2, CHLORIDE ION, ...
Authors:Shrestha, R.K, Das, C.
Deposit date:2013-04-05
Release date:2014-04-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.632 Å)
Cite:Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product.
Biochemistry, 53, 2014

223532

數據於2024-08-07公開中

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