7NPI

Crystal structure of Mindy2 (C266A) in complex with Lys48-linked penta-ubiquitin (K48-Ub5)

Summary for 7NPI

Entry DOI	10.2210/pdb7npi/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase MINDY-2, Polyubiquitin-C, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	ubiquitin, branched, heterotypic, nanobody, synthetic nanobody, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	42
Total formula weight	518484.69
Authors	Lange, S.M.,Armstrong, L.A.,Kulathu, Y. (deposition date: 2021-02-26, release date: 2021-09-15, Last modification date: 2024-01-31)
Primary citation	Abdul Rehman, S.A.,Armstrong, L.A.,Lange, S.M.,Kristariyanto, Y.A.,Grawert, T.W.,Knebel, A.,Svergun, D.I.,Kulathu, Y. Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol.Cell, 81:4176-4190.e6, 2021 Cited by PubMed: 34529927 DOI: 10.1016/j.molcel.2021.08.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation