7NPI
Crystal structure of Mindy2 (C266A) in complex with Lys48-linked penta-ubiquitin (K48-Ub5)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 1990380 | molecular_function | K48-linked deubiquitinase activity |
| G | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| G | 1990380 | molecular_function | K48-linked deubiquitinase activity |
| M | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| M | 1990380 | molecular_function | K48-linked deubiquitinase activity |
| S | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| S | 1990380 | molecular_function | K48-linked deubiquitinase activity |
| Y | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| Y | 1990380 | molecular_function | K48-linked deubiquitinase activity |
| e | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| e | 1990380 | molecular_function | K48-linked deubiquitinase activity |
| k | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| k | 1990380 | molecular_function | K48-linked deubiquitinase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| a | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| B | ARG54 | |
| F | ARG72 | |
| H | ARG54 | |
| H | ARG72 | |
| I | ARG54 | |
| I | ARG72 | |
| J | ARG54 | |
| J | ARG72 | |
| K | ARG54 | |
| K | ARG72 | |
| L | ARG54 | |
| B | ARG72 | |
| L | ARG72 | |
| N | ARG54 | |
| N | ARG72 | |
| O | ARG54 | |
| O | ARG72 | |
| P | ARG54 | |
| P | ARG72 | |
| Q | ARG54 | |
| Q | ARG72 | |
| R | ARG54 | |
| C | ARG54 | |
| R | ARG72 | |
| T | ARG54 | |
| T | ARG72 | |
| U | ARG54 | |
| U | ARG72 | |
| V | ARG54 | |
| V | ARG72 | |
| W | ARG54 | |
| W | ARG72 | |
| X | ARG54 | |
| C | ARG72 | |
| X | ARG72 | |
| Z | ARG54 | |
| Z | ARG72 | |
| a | ARG54 | |
| a | ARG72 | |
| b | ARG54 | |
| b | ARG72 | |
| c | ARG54 | |
| c | ARG72 | |
| d | ARG54 | |
| D | ARG54 | |
| d | ARG72 | |
| f | ARG54 | |
| f | ARG72 | |
| g | ARG54 | |
| g | ARG72 | |
| h | ARG54 | |
| h | ARG72 | |
| i | ARG54 | |
| i | ARG72 | |
| j | ARG54 | |
| D | ARG72 | |
| j | ARG72 | |
| l | ARG54 | |
| l | ARG72 | |
| m | ARG54 | |
| m | ARG72 | |
| n | ARG54 | |
| n | ARG72 | |
| o | ARG54 | |
| o | ARG72 | |
| p | ARG54 | |
| E | ARG54 | |
| p | ARG72 | |
| E | ARG72 | |
| F | ARG54 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| B | HIS68 | |
| L | HIS68 | |
| N | HIS68 | |
| O | HIS68 | |
| P | HIS68 | |
| Q | HIS68 | |
| R | HIS68 | |
| T | HIS68 | |
| U | HIS68 | |
| V | HIS68 | |
| W | HIS68 | |
| C | HIS68 | |
| X | HIS68 | |
| Z | HIS68 | |
| a | HIS68 | |
| b | HIS68 | |
| c | HIS68 | |
| d | HIS68 | |
| f | HIS68 | |
| g | HIS68 | |
| h | HIS68 | |
| i | HIS68 | |
| D | HIS68 | |
| j | HIS68 | |
| l | HIS68 | |
| m | HIS68 | |
| n | HIS68 | |
| o | HIS68 | |
| p | HIS68 | |
| E | HIS68 | |
| F | HIS68 | |
| H | HIS68 | |
| I | HIS68 | |
| J | HIS68 | |
| K | HIS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
| Chain | Residue | Details |
| B | SER65 | |
| L | SER65 | |
| N | SER65 | |
| O | SER65 | |
| P | SER65 | |
| Q | SER65 | |
| R | SER65 | |
| T | SER65 | |
| U | SER65 | |
| V | SER65 | |
| W | SER65 | |
| C | SER65 | |
| X | SER65 | |
| Z | SER65 | |
| a | SER65 | |
| b | SER65 | |
| c | SER65 | |
| d | SER65 | |
| f | SER65 | |
| g | SER65 | |
| h | SER65 | |
| i | SER65 | |
| D | SER65 | |
| j | SER65 | |
| l | SER65 | |
| m | SER65 | |
| n | SER65 | |
| o | SER65 | |
| p | SER65 | |
| E | SER65 | |
| F | SER65 | |
| H | SER65 | |
| I | SER65 | |
| J | SER65 | |
| K | SER65 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
| Chain | Residue | Details |
| B | THR66 | |
| L | THR66 | |
| N | THR66 | |
| O | THR66 | |
| P | THR66 | |
| Q | THR66 | |
| R | THR66 | |
| T | THR66 | |
| U | THR66 | |
| V | THR66 | |
| W | THR66 | |
| C | THR66 | |
| X | THR66 | |
| Z | THR66 | |
| a | THR66 | |
| b | THR66 | |
| c | THR66 | |
| d | THR66 | |
| f | THR66 | |
| g | THR66 | |
| h | THR66 | |
| i | THR66 | |
| D | THR66 | |
| j | THR66 | |
| l | THR66 | |
| m | THR66 | |
| n | THR66 | |
| o | THR66 | |
| p | THR66 | |
| E | THR66 | |
| F | THR66 | |
| H | THR66 | |
| I | THR66 | |
| J | THR66 | |
| K | THR66 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 35 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
| Chain | Residue | Details |
| B | GLY76 | |
| L | GLY76 | |
| N | GLY76 | |
| O | GLY76 | |
| P | GLY76 | |
| Q | GLY76 | |
| R | GLY76 | |
| T | GLY76 | |
| U | GLY76 | |
| V | GLY76 | |
| W | GLY76 | |
| C | GLY76 | |
| X | GLY76 | |
| Z | GLY76 | |
| a | GLY76 | |
| b | GLY76 | |
| c | GLY76 | |
| d | GLY76 | |
| f | GLY76 | |
| g | GLY76 | |
| h | GLY76 | |
| i | GLY76 | |
| D | GLY76 | |
| j | GLY76 | |
| l | GLY76 | |
| m | GLY76 | |
| n | GLY76 | |
| o | GLY76 | |
| p | GLY76 | |
| E | GLY76 | |
| F | GLY76 | |
| H | GLY76 | |
| I | GLY76 | |
| J | GLY76 | |
| K | GLY76 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 35 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| B | LYS6 | |
| L | LYS6 | |
| N | LYS6 | |
| O | LYS6 | |
| P | LYS6 | |
| Q | LYS6 | |
| R | LYS6 | |
| T | LYS6 | |
| U | LYS6 | |
| V | LYS6 | |
| W | LYS6 | |
| C | LYS6 | |
| X | LYS6 | |
| Z | LYS6 | |
| a | LYS6 | |
| b | LYS6 | |
| c | LYS6 | |
| d | LYS6 | |
| f | LYS6 | |
| g | LYS6 | |
| h | LYS6 | |
| i | LYS6 | |
| D | LYS6 | |
| j | LYS6 | |
| l | LYS6 | |
| m | LYS6 | |
| n | LYS6 | |
| o | LYS6 | |
| p | LYS6 | |
| E | LYS6 | |
| F | LYS6 | |
| H | LYS6 | |
| I | LYS6 | |
| J | LYS6 | |
| K | LYS6 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 70 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| F | GLY76 | |
| H | GLY76 | |
| I | GLY76 | |
| J | GLY76 | |
| K | GLY76 | |
| B | GLY76 | |
| L | GLY76 | |
| N | GLY76 | |
| O | GLY76 | |
| P | GLY76 | |
| Q | GLY76 | |
| R | GLY76 | |
| T | GLY76 | |
| U | GLY76 | |
| V | GLY76 | |
| W | GLY76 | |
| C | GLY76 | |
| X | GLY76 | |
| Z | GLY76 | |
| a | GLY76 | |
| b | GLY76 | |
| c | GLY76 | |
| d | GLY76 | |
| f | GLY76 | |
| g | GLY76 | |
| h | GLY76 | |
| i | GLY76 | |
| D | GLY76 | |
| j | GLY76 | |
| l | GLY76 | |
| m | GLY76 | |
| n | GLY76 | |
| o | GLY76 | |
| p | GLY76 | |
| E | GLY76 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 70 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| B | LYS11 | |
| F | LYS48 | |
| H | LYS11 | |
| H | LYS48 | |
| I | LYS11 | |
| I | LYS48 | |
| J | LYS11 | |
| J | LYS48 | |
| K | LYS11 | |
| K | LYS48 | |
| L | LYS11 | |
| B | LYS48 | |
| L | LYS48 | |
| N | LYS11 | |
| N | LYS48 | |
| O | LYS11 | |
| O | LYS48 | |
| P | LYS11 | |
| P | LYS48 | |
| Q | LYS11 | |
| Q | LYS48 | |
| R | LYS11 | |
| C | LYS11 | |
| R | LYS48 | |
| T | LYS11 | |
| T | LYS48 | |
| U | LYS11 | |
| U | LYS48 | |
| V | LYS11 | |
| V | LYS48 | |
| W | LYS11 | |
| W | LYS48 | |
| X | LYS11 | |
| C | LYS48 | |
| X | LYS48 | |
| Z | LYS11 | |
| Z | LYS48 | |
| a | LYS11 | |
| a | LYS48 | |
| b | LYS11 | |
| b | LYS48 | |
| c | LYS11 | |
| c | LYS48 | |
| d | LYS11 | |
| D | LYS11 | |
| d | LYS48 | |
| f | LYS11 | |
| f | LYS48 | |
| g | LYS11 | |
| g | LYS48 | |
| h | LYS11 | |
| h | LYS48 | |
| i | LYS11 | |
| i | LYS48 | |
| j | LYS11 | |
| D | LYS48 | |
| j | LYS48 | |
| l | LYS11 | |
| l | LYS48 | |
| m | LYS11 | |
| m | LYS48 | |
| n | LYS11 | |
| n | LYS48 | |
| o | LYS11 | |
| o | LYS48 | |
| p | LYS11 | |
| E | LYS11 | |
| p | LYS48 | |
| E | LYS48 | |
| F | LYS11 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 35 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| B | LYS27 | |
| L | LYS27 | |
| N | LYS27 | |
| O | LYS27 | |
| P | LYS27 | |
| Q | LYS27 | |
| R | LYS27 | |
| T | LYS27 | |
| U | LYS27 | |
| V | LYS27 | |
| W | LYS27 | |
| C | LYS27 | |
| X | LYS27 | |
| Z | LYS27 | |
| a | LYS27 | |
| b | LYS27 | |
| c | LYS27 | |
| d | LYS27 | |
| f | LYS27 | |
| g | LYS27 | |
| h | LYS27 | |
| i | LYS27 | |
| D | LYS27 | |
| j | LYS27 | |
| l | LYS27 | |
| m | LYS27 | |
| n | LYS27 | |
| o | LYS27 | |
| p | LYS27 | |
| E | LYS27 | |
| F | LYS27 | |
| H | LYS27 | |
| I | LYS27 | |
| J | LYS27 | |
| K | LYS27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 35 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| B | LYS29 | |
| L | LYS29 | |
| N | LYS29 | |
| O | LYS29 | |
| P | LYS29 | |
| Q | LYS29 | |
| R | LYS29 | |
| T | LYS29 | |
| U | LYS29 | |
| V | LYS29 | |
| W | LYS29 | |
| C | LYS29 | |
| X | LYS29 | |
| Z | LYS29 | |
| a | LYS29 | |
| b | LYS29 | |
| c | LYS29 | |
| d | LYS29 | |
| f | LYS29 | |
| g | LYS29 | |
| h | LYS29 | |
| i | LYS29 | |
| D | LYS29 | |
| j | LYS29 | |
| l | LYS29 | |
| m | LYS29 | |
| n | LYS29 | |
| o | LYS29 | |
| p | LYS29 | |
| E | LYS29 | |
| F | LYS29 | |
| H | LYS29 | |
| I | LYS29 | |
| J | LYS29 | |
| K | LYS29 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 35 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| B | LYS33 | |
| L | LYS33 | |
| N | LYS33 | |
| O | LYS33 | |
| P | LYS33 | |
| Q | LYS33 | |
| R | LYS33 | |
| T | LYS33 | |
| U | LYS33 | |
| V | LYS33 | |
| W | LYS33 | |
| C | LYS33 | |
| X | LYS33 | |
| Z | LYS33 | |
| a | LYS33 | |
| b | LYS33 | |
| c | LYS33 | |
| d | LYS33 | |
| f | LYS33 | |
| g | LYS33 | |
| h | LYS33 | |
| i | LYS33 | |
| D | LYS33 | |
| j | LYS33 | |
| l | LYS33 | |
| m | LYS33 | |
| n | LYS33 | |
| o | LYS33 | |
| p | LYS33 | |
| E | LYS33 | |
| F | LYS33 | |
| H | LYS33 | |
| I | LYS33 | |
| J | LYS33 | |
| K | LYS33 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 35 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| B | LYS63 | |
| L | LYS63 | |
| N | LYS63 | |
| O | LYS63 | |
| P | LYS63 | |
| Q | LYS63 | |
| R | LYS63 | |
| T | LYS63 | |
| U | LYS63 | |
| V | LYS63 | |
| W | LYS63 | |
| C | LYS63 | |
| X | LYS63 | |
| Z | LYS63 | |
| a | LYS63 | |
| b | LYS63 | |
| c | LYS63 | |
| d | LYS63 | |
| f | LYS63 | |
| g | LYS63 | |
| h | LYS63 | |
| i | LYS63 | |
| D | LYS63 | |
| j | LYS63 | |
| l | LYS63 | |
| m | LYS63 | |
| n | LYS63 | |
| o | LYS63 | |
| p | LYS63 | |
| E | LYS63 | |
| F | LYS63 | |
| H | LYS63 | |
| I | LYS63 | |
| J | LYS63 | |
| K | LYS63 |
