6TYG
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![BU of 6tyg by Molmil](/molmil-images/mine/6tyg) | Crystal structure of MTB sigma L transcription initiation complex with 9 nt long RNA primer | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Molodtsov, V, Ebright, R.H. | Deposit date: | 2019-08-08 | Release date: | 2020-03-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
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6TYE
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![BU of 6tye by Molmil](/molmil-images/mine/6tye) | Crystal structure of MTB sigma L transcription initiation complex with 5 nt long RNA primer | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Molodtsov, V, Ebright, R.H. | Deposit date: | 2019-08-08 | Release date: | 2020-03-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.79 Å) | Cite: | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
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1K8W
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1MT4
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![BU of 1mt4 by Molmil](/molmil-images/mine/1mt4) | Structure of 23S ribosomal RNA hairpin 35 | Descriptor: | 23S ribosomal Hairpin 35 | Authors: | Lebars, I, Yoshizawa, S, Stenholm, A.R, Guittet, E, Douthwaite, S, Fourmy, D. | Deposit date: | 2002-09-20 | Release date: | 2003-01-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII Embo J., 22, 2003
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8FIY
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![BU of 8fiy by Molmil](/molmil-images/mine/8fiy) | Cryo-EM structure of E. coli RNA polymerase Elongation complex in the Transcription-Translation Complex (RNAP in an anti-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Florez Ariza, A, Wee, L, Tong, A, Canari, C, Grob, P, Nogales, E, Bustamante, C. | Deposit date: | 2022-12-17 | Release date: | 2023-03-29 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (7.3 Å) | Cite: | A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Cell, 186, 2023
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8GZR
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![BU of 8gzr by Molmil](/molmil-images/mine/8gzr) | Cryo-EM structure of the the NS5-NS3 RNA-elongation complex | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ... | Authors: | Osawa, T, Ehara, H, Sekine, S. | Deposit date: | 2022-09-27 | Release date: | 2023-08-02 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
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5OC5
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5OC4
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![BU of 5oc4 by Molmil](/molmil-images/mine/5oc4) | Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD R361A-R362A mutant | Descriptor: | CACODYLATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Bou-nader, C, Pecqueur, L, Hamdane, D. | Deposit date: | 2017-06-29 | Release date: | 2018-12-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2. Nucleic Acids Res., 47, 2019
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1Y1V
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![BU of 1y1v by Molmil](/molmil-images/mine/1y1v) | Refined RNA Polymerase II-TFIIS complex | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | Authors: | Kettenberger, H, Armache, K.-J, Cramer, P. | Deposit date: | 2004-11-19 | Release date: | 2004-12-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol.Cell, 16, 2004
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4PKD
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![BU of 4pkd by Molmil](/molmil-images/mine/4pkd) | U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2 | Descriptor: | IMIDAZOLE, MAGNESIUM ION, U1 small nuclear ribonucleoprotein A,U1 small nuclear ribonucleoprotein 70 kDa, ... | Authors: | Oubridge, C, Kondo, Y, van Roon, A.M, Nagai, K. | Deposit date: | 2014-05-14 | Release date: | 2014-12-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. Elife, 4, 2015
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3Q2T
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![BU of 3q2t by Molmil](/molmil-images/mine/3q2t) | Crystal Structure of CFIm68 RRM/CFIm25/RNA complex | Descriptor: | Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 6, RNA | Authors: | Yang, Q, Coseno, M, Gilmartin, G.M, Doublie, S. | Deposit date: | 2010-12-20 | Release date: | 2011-02-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.061 Å) | Cite: | Crystal Structure of a Human Cleavage Factor CFI(m)25/CFI(m)68/RNA Complex Provides an Insight into Poly(A) Site Recognition and RNA Looping. Structure, 19, 2011
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3V11
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![BU of 3v11 by Molmil](/molmil-images/mine/3v11) | |
8HSG
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![BU of 8hsg by Molmil](/molmil-images/mine/8hsg) | Thermus thermophilus RNA polymerase elongation complex | Descriptor: | DNA (27-MER), DNA (37-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Murayama, Y, Ehara, H, Sekine, S. | Deposit date: | 2022-12-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8HSL
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![BU of 8hsl by Molmil](/molmil-images/mine/8hsl) | Thermus thermophilus RNA polymerase bound with an inverted Rho hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Murayama, Y, Ehara, H, Sekine, S. | Deposit date: | 2022-12-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8HSR
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![BU of 8hsr by Molmil](/molmil-images/mine/8hsr) | Thermus thermophilus Rho-engaged RNAP elongation complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... | Authors: | Murayama, Y, Ehara, H, Sekine, S. | Deposit date: | 2022-12-20 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8FIX
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![BU of 8fix by Molmil](/molmil-images/mine/8fix) | Cryo-EM structure of E. coli RNA polymerase backtracked elongation complex harboring a terminal mismatch | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Florez Ariza, A, Wee, L, Tong, A, Canari, C, Grob, P, Nogales, E, Bustamante, C. | Deposit date: | 2022-12-17 | Release date: | 2023-03-29 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Cell, 186, 2023
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7AAV
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![BU of 7aav by Molmil](/molmil-images/mine/7aav) | Human pre-Bact-2 spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-04 | Release date: | 2020-12-09 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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6NSX
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5X6C
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![BU of 5x6c by Molmil](/molmil-images/mine/5x6c) | Crystal structure of SepRS-SepCysE from Methanocaldococcus jannaschii | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, O-phosphoserine--tRNA(Cys) ligase, SULFATE ION, ... | Authors: | Chen, M, Kato, K, Yao, M. | Deposit date: | 2017-02-21 | Release date: | 2017-12-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.101 Å) | Cite: | Structural basis for tRNA-dependent cysteine biosynthesis Nat Commun, 8, 2017
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4PZ6
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![BU of 4pz6 by Molmil](/molmil-images/mine/4pz6) | |
6KQF
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![BU of 6kqf by Molmil](/molmil-images/mine/6kqf) | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 5 nt | Descriptor: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Zhang, Y, Li, L, Ebright, R.H. | Deposit date: | 2019-08-17 | Release date: | 2020-03-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
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6NY5
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6L74
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![BU of 6l74 by Molmil](/molmil-images/mine/6l74) | Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 2 nt | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Zhang, Y, Li, L, Ebright, R.H. | Deposit date: | 2019-10-31 | Release date: | 2020-03-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
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8HSH
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![BU of 8hsh by Molmil](/molmil-images/mine/8hsh) | Thermus thermophilus RNA polymerase coreenzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Murayama, Y, Ehara, H, Sekine, S. | Deposit date: | 2022-12-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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354D
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![BU of 354d by Molmil](/molmil-images/mine/354d) | Structure of loop E FROM E. coli 5S RRNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*G)-3'), RNA-DNA (5'-R(*GP*CP*GP*AP*GP*AP*GP*UP*AP*)-D(*DGP(S)*)-R(*GP*C)-3') | Authors: | Correll, C.C, Freeborn, B, Moore, P.B, Steitz, T.A. | Deposit date: | 1997-10-01 | Release date: | 1997-11-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Metals, motifs, and recognition in the crystal structure of a 5S rRNA domain. Cell(Cambridge,Mass.), 91, 1997
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