6TYG

Crystal structure of MTB sigma L transcription initiation complex with 9 nt long RNA primer

Summary for 6TYG

• Entry DOI: 10.2210/pdb6tyg/pdb
• Descriptor: RNA polymerase sigma factor, DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), ... (8 entities in total)
• Functional Keywords: transcription, tuberculosis, initiation, sigma finger displacement
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 9
• Total formula weight: 401271.80

Authors

Molodtsov, V.,Ebright, R.H. (deposition date: 2019-08-08, release date: 2020-03-11, Last modification date: 2023-10-11)

• Primary citation: Li, L.,Molodtsov, V.,Lin, W.,Ebright, R.H.,Zhang, Y.; RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.; Proc.Natl.Acad.Sci.USA, 117:5801-5809, 2020; PubMed: 32127479; DOI: 10.1073/pnas.1920747117

Experimental method

X-RAY DIFFRACTION (3.5 Å)