6OLZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6olz by Molmil](/molmil-images/mine/6olz) | |
8XSZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8xsz by Molmil](/molmil-images/mine/8xsz) | Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
6OLG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6olg by Molmil](/molmil-images/mine/6olg) | |
7RSR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rsr by Molmil](/molmil-images/mine/7rsr) | Kod-RI incorporating PMT, n+2 | Descriptor: | DNA polymerase, Primer, Template | Authors: | Hajjar, M, Chim, N, Chaput, J.C. | Deposit date: | 2021-08-11 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid. Nucleic Acids Res., 50, 2022
|
|
7RSS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rss by Molmil](/molmil-images/mine/7rss) | Kod-RI incorporating DNA, n+2 | Descriptor: | DNA polymerase, Primer, Template | Authors: | Hajjar, M, Chim, N, Chaput, J.C. | Deposit date: | 2021-08-11 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid. Nucleic Acids Res., 50, 2022
|
|
8SQ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8sq9 by Molmil](/molmil-images/mine/8sq9) | SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Small, G.I, Darst, S.A, Campbell, E.A. | Deposit date: | 2023-05-04 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
|
|
7A01
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7a01 by Molmil](/molmil-images/mine/7a01) | The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism | Descriptor: | 18S RIBOSOMAL RNA, 28S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN ES21, ... | Authors: | Abaeva, I, Vicens, Q, Bochler, A, Soufari, H, Simonetti, A, Pestova, T.V, Hashem, Y, Hellen, C.U.T. | Deposit date: | 2020-08-05 | Release date: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism. Cell Rep, 33, 2020
|
|
8RNH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8rnh by Molmil](/molmil-images/mine/8rnh) | Crystal structure of HLA B*18:01 in complex with EEIEITTHF, an 9-mer epitope from Influenza A | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Murdolo, L.D, Maddumaage, J, Gras, S. | Deposit date: | 2024-01-10 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes. Clin Transl Immunology, 13, 2024
|
|
6DX5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dx5 by Molmil](/molmil-images/mine/6dx5) | Crystal structure of the viral OTU domain protease from Farallon virus | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RNA-dependent RNA polymerase | Authors: | Beldon, B.S, Dzimianski, J.V, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | Deposit date: | 2018-06-28 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.224 Å) | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. PLoS Pathog., 15, 2019
|
|
6DX3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dx3 by Molmil](/molmil-images/mine/6dx3) | Crystal structure of the viral OTU domain protease from Taggert virus | Descriptor: | MAGNESIUM ION, RNA-dependent RNA polymerase | Authors: | Dzimianski, J.V, Beldon, B.S, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | Deposit date: | 2018-06-28 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. PLoS Pathog., 15, 2019
|
|
6MTB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mtb by Molmil](/molmil-images/mine/6mtb) | Rabbit 80S ribosome with P- and Z-site tRNAs (unrotated state) | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Brown, A, Baird, M.R, Yip, M.C.J, Murray, J, Shao, S. | Deposit date: | 2018-10-19 | Release date: | 2018-11-21 | Last modified: | 2019-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of translationally inactive mammalian ribosomes. Elife, 7, 2018
|
|
6MTC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mtc by Molmil](/molmil-images/mine/6mtc) | Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state) | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Brown, A, Baird, M.R, Yip, M.C.J, Murray, J, Shao, S. | Deposit date: | 2018-10-19 | Release date: | 2018-11-21 | Last modified: | 2019-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of translationally inactive mammalian ribosomes. Elife, 7, 2018
|
|
6Q8Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6q8y by Molmil](/molmil-images/mine/6q8y) | Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Tesina, P, Heckel, E, Cheng, J, Buschauer, R, Kater, L, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2018-12-16 | Release date: | 2019-03-13 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the 80S ribosome-Xrn1 nuclease complex. Nat.Struct.Mol.Biol., 26, 2019
|
|
6HCJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hcj by Molmil](/molmil-images/mine/6hcj) | Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. | Deposit date: | 2018-08-15 | Release date: | 2018-10-17 | Last modified: | 2018-11-14 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Mol. Cell, 72, 2018
|
|
4W9S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4w9s by Molmil](/molmil-images/mine/4w9s) | 2-(4-(1H-tetrazol-5-yl)phenyl)-5-hydroxypyrimidin-4(3H)-one bound to influenza 2009 H1N1 endonuclease | Descriptor: | 5-hydroxy-2-[4-(1H-tetrazol-5-yl)phenyl]pyrimidin-4(3H)-one, MANGANESE (II) ION, Polymerase acidic protein, ... | Authors: | Bauman, J.D, Patel, D, Das, K, Arnold, E. | Deposit date: | 2014-08-27 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease. J.Med.Chem., 57, 2014
|
|
6H25
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6h25 by Molmil](/molmil-images/mine/6h25) | Human nuclear RNA exosome EXO-10-MPP6 complex | Descriptor: | Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... | Authors: | Gerlach, P, Schuller, J.M, Falk, S, Basquin, J, Conti, E. | Deposit date: | 2018-07-13 | Release date: | 2018-08-15 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Distinct and evolutionary conserved structural features of the human nuclear exosome complex. Elife, 7, 2018
|
|
5A22
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a22 by Molmil](/molmil-images/mine/5a22) | Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy | Descriptor: | VESICULAR STOMATITIS VIRUS L POLYMERASE, ZINC ION | Authors: | Liang, B, Li, Z, Jenni, S, Rameh, A.A, Morin, B.M, Grant, T, Grigorieff, N, Harrison, S.C, Whelan, S.P.J. | Deposit date: | 2015-05-06 | Release date: | 2015-08-19 | Last modified: | 2019-04-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell(Cambridge,Mass.), 162, 2015
|
|
4PUO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4puo by Molmil](/molmil-images/mine/4puo) | Crystal structure of HIV-1 reverse transcriptase in complex with RNA/DNA and Nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3', 5'-R(P*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*UP*GP*UP*G)-3', ... | Authors: | Das, K, Martinez, S.E, Arnold, E. | Deposit date: | 2014-03-13 | Release date: | 2014-06-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.901 Å) | Cite: | Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. Nucleic Acids Res., 42, 2014
|
|
4Q0B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q0b by Molmil](/molmil-images/mine/4q0b) | Crystal structure of HIV-1 reverse transcriptase in complex with gap-RNA/DNA and Nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3', 5'-R(*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*G)-3', ... | Authors: | Das, K, Martinez, S.E, Arnold, E. | Deposit date: | 2014-04-01 | Release date: | 2014-06-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. Nucleic Acids Res., 42, 2014
|
|
4PWD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pwd by Molmil](/molmil-images/mine/4pwd) | Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3', 5'-R(*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*AP*CP*AP*GP*GP*GP*AP*CP*UP*GP*U)-3', ... | Authors: | Das, K, Martinez, S.E, Arnold, E. | Deposit date: | 2014-03-19 | Release date: | 2014-06-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. Nucleic Acids Res., 42, 2014
|
|
6HCF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hcf by Molmil](/molmil-images/mine/6hcf) | Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. | Deposit date: | 2018-08-14 | Release date: | 2018-10-17 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Mol. Cell, 72, 2018
|
|
5W6Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5w6q by Molmil](/molmil-images/mine/5w6q) | |
6R0N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6r0n by Molmil](/molmil-images/mine/6r0n) | Histone fold domain of AtNF-YB2/NF-YC3 in I2 | Descriptor: | GLYCEROL, NF-YB2, NF-YC3 | Authors: | Chaves-Sanjuan, A, Gnesutta, N, Bernardini, A, Fornara, F, Nardini, M, Mantovani, R. | Deposit date: | 2019-03-13 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural determinants for NF-Y subunit organization and NF-Y/DNA association in plants. Plant J., 105, 2021
|
|
6R0M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6r0m by Molmil](/molmil-images/mine/6r0m) | Histone fold domain of AtNF-YB2/NF-YC3 in P212121 | Descriptor: | NF-YB2, NF-YC3 | Authors: | Chaves-Sanjuan, A, Gnesutta, N, Chiara, M, Bernardini, A, Fornara, F, Horner, D, Nardini, M, Mantovani, R. | Deposit date: | 2019-03-13 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural determinants for NF-Y subunit organization and NF-Y/DNA association in plants. Plant J., 105, 2021
|
|
6R2V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6r2v by Molmil](/molmil-images/mine/6r2v) | Arabidopsis NF-Y/CCAAT-box complex | Descriptor: | FT (-5kb) CCAAT-box 3', FT (-5kb) CCAAT-box 5', NF-YB2, ... | Authors: | Chaves-Sanjuan, A, Gnesutta, N, Chiara, M, Bernardini, A, Fornara, F, Horner, D, Nardini, M, Mantovani, R. | Deposit date: | 2019-03-19 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Structural determinants for NF-Y subunit organization and NF-Y/DNA association in plants. Plant J., 105, 2021
|
|