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3FQG
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BU of 3fqg by Molmil
Crystal Structure of the S. pombe Rai1
Descriptor: MAGNESIUM ION, Protein din1
Authors:Xiang, S, Tong, L.
Deposit date:2009-01-07
Release date:2009-02-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
Nature, 458, 2009
3FQD
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BU of 3fqd by Molmil
Crystal Structure of the S. pombe Rat1-Rai1 Complex
Descriptor: 5'-3' exoribonuclease 2, GLYCEROL, MAGNESIUM ION, ...
Authors:Xiang, S, Tong, L.
Deposit date:2009-01-07
Release date:2009-02-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
Nature, 458, 2009
7JTP
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BU of 7jtp by Molmil
Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Descriptor: Elongin-B, Elongin-C, GLYCEROL, ...
Authors:Kottur, J, Jain, R, Aggarwal, A.K.
Deposit date:2020-08-18
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
7JTO
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BU of 7jto by Molmil
Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Descriptor: 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ...
Authors:Kottur, J, Jain, R, Aggarwal, A.K.
Deposit date:2020-08-18
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
7YI1
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BU of 7yi1 by Molmil
Cryo-EM structure of Eaf3 CHD bound to H3K36me3 nucleosome
Descriptor: Chromatin modification-related protein EAF3, Histone H2A, Histone H2B 1.1, ...
Authors:Li, H.T, Yan, C.Y, Guan, H.P, Wang, P.
Deposit date:2022-07-14
Release date:2023-06-14
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Nature, 620, 2023
8G87
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BU of 8g87 by Molmil
Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region)
Descriptor: POU domain, class 5, transcription factor 1, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8FON
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BU of 8fon by Molmil
Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Nguyen, H.A, Hoffer, E.D, Maehigashi, T, Fagan, C.E, Dunham, C.M.
Deposit date:2023-01-02
Release date:2023-03-29
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches.
J.Biol.Chem., 299, 2023
5IFE
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BU of 5ife by Molmil
Crystal structure of the human SF3b core complex
Descriptor: PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ...
Authors:Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V.
Deposit date:2016-02-25
Release date:2016-10-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Mol.Cell, 64, 2016
7R5K
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BU of 7r5k by Molmil
Human nuclear pore complex (constricted)
Descriptor: Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ...
Authors:Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M.
Deposit date:2022-02-10
Release date:2022-06-22
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (12 Å)
Cite:AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
Science, 376, 2022
7R5J
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BU of 7r5j by Molmil
Human nuclear pore complex (dilated)
Descriptor: Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ...
Authors:Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M.
Deposit date:2022-02-10
Release date:2022-09-21
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (50 Å)
Cite:AI-based structure prediction empowers integrative structural analysis of human nuclear pores
Science, 376, 2022
8OR2
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BU of 8or2 by Molmil
CAND1-CUL1-RBX1-DCNL1
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, DCN1-like protein 1, ...
Authors:Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I.
Deposit date:2023-04-12
Release date:2023-06-28
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.
Mol.Cell, 83, 2023
8FOM
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BU of 8fom by Molmil
Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Nguyen, H.A, Hoffer, E.D, Maehigashi, T, Fagan, C.E, Dunham, C.M.
Deposit date:2023-01-02
Release date:2023-03-29
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches.
J.Biol.Chem., 299, 2023
4OLB
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BU of 4olb by Molmil
Crystal Structure of Human Argonaute2 Bound to Tryptophan
Descriptor: 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', Protein argonaute-2, TRYPTOPHAN
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-01-23
Release date:2014-02-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:The crystal structure of human Argonaute2.
Science, 336, 2012
6Z45
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BU of 6z45 by Molmil
CDK9-Cyclin-T1 complex bound by compound 24
Descriptor: (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ...
Authors:Ferguson, A, Collie, G.W.
Deposit date:2020-05-22
Release date:2020-12-23
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J.Med.Chem., 63, 2020
1N54
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BU of 1n54 by Molmil
Cap Binding Complex m7GpppG free
Descriptor: 20 kDa nuclear cap binding protein, 80 kDa nuclear cap binding protein, GLYCEROL
Authors:Calero, G, Wilson, K, Ly, T, Rios-Steiner, J, Clardy, J, Cerione, R.
Deposit date:2002-11-04
Release date:2003-02-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
8VOJ
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BU of 8voj by Molmil
The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6
Descriptor: (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Xie, X, Mao, H, Liau, B, Zheng, N.
Deposit date:2024-01-15
Release date:2024-12-04
Last modified:2025-06-18
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
Nature, 639, 2025
6TCA
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BU of 6tca by Molmil
Phosphorylated p38 and MAPKAPK2 complex with inhibitor
Descriptor: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide
Authors:Sok, P, Remenyi, A.
Deposit date:2019-11-05
Release date:2020-07-22
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Structure, 28, 2020
7NFC
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BU of 7nfc by Molmil
Cryo-EM structure of NHEJ super-complex (dimer)
Descriptor: DNA (27-MER), DNA (28-MER), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-05
Release date:2021-08-18
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
3MWV
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BU of 3mwv by Molmil
Crystal structure of HCV NS5B polymerase
Descriptor: Genome polyprotein
Authors:Coulombe, R.
Deposit date:2010-05-06
Release date:2010-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.
J.Am.Chem.Soc., 132, 2010
8FVI
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BU of 8fvi by Molmil
Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5
Descriptor: Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ...
Authors:Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S.
Deposit date:2023-01-19
Release date:2023-09-06
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.
Nat Commun, 14, 2023
6M91
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BU of 6m91 by Molmil
Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex
Descriptor: 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid, CHLORIDE ION, Catenin beta-1, ...
Authors:Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J.
Deposit date:2018-08-22
Release date:2019-04-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
Nat Commun, 10, 2019
8T12
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BU of 8t12 by Molmil
Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered.
Descriptor: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION
Authors:Biswal, M, Lu, J, Song, J.
Deposit date:2023-06-01
Release date:2024-01-17
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.
Commun Biol, 7, 2024
8T13
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BU of 8t13 by Molmil
Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered
Descriptor: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION
Authors:Biswal, M, Lu, J, Song, J.
Deposit date:2023-06-01
Release date:2024-01-17
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.
Commun Biol, 7, 2024
8UIB
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BU of 8uib by Molmil
Structure of the human INTS9-INTS11-BRAT1 complex
Descriptor: BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ...
Authors:Lin, M, Tong, L.
Deposit date:2023-10-10
Release date:2024-08-21
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Mol.Cell, 84, 2024
7NFE
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BU of 7nfe by Molmil
Cryo-EM structure of NHEJ super-complex (monomer)
Descriptor: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-06
Release date:2021-08-18
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021

238582

數據於2025-07-09公開中

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