6M91

Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex

Summary for 6M91

• Entry DOI: 10.2210/pdb6m91/pdb
• Descriptor: F-box/WD repeat-containing protein 1A, S-phase kinase-associated protein 1, Catenin beta-1, ... (7 entities in total)
• Functional Keywords: ubiquitin molecular glue enhancer, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 70040.58

Authors

Simonetta, K.R.,Clifton, M.C.,Walter, R.L.,Ranieri, G.M.,Carter, J.J. (deposition date: 2018-08-22, release date: 2019-04-03, Last modification date: 2019-04-10)

• Primary citation: Simonetta, K.R.,Taygerly, J.,Boyle, K.,Basham, S.E.,Padovani, C.,Lou, Y.,Cummins, T.J.,Yung, S.L.,von Soly, S.K.,Kayser, F.,Kuriyan, J.,Rape, M.,Cardozo, M.,Gallop, M.A.,Bence, N.F.,Barsanti, P.A.,Saha, A.; Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.; Nat Commun, 10:1402-1402, 2019; PubMed: 30926793; DOI: 10.1038/s41467-019-09358-9

Experimental method

X-RAY DIFFRACTION (2.4 Å)