8T12

Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered.

Summary for 8T12

• Entry DOI: 10.2210/pdb8t12/pdb
• EMDB information: 40952
• Descriptor: Signal transducer and activator of transcription 2, Non-structural protein 5, ZINC ION (3 entities in total)
• Functional Keywords: complex, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 201420.51

Authors

Biswal, M.,Lu, J.,Song, J. (deposition date: 2023-06-01, release date: 2024-01-17, Last modification date: 2024-07-31)

• Primary citation: Biswal, M.,Yao, W.,Lu, J.,Chen, J.,Morrison, J.,Hai, R.,Song, J.; A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.; Commun Biol, 7:76-76, 2024; PubMed: 38195857; DOI: 10.1038/s42003-024-05768-8

Experimental method

ELECTRON MICROSCOPY (3.34 Å)