8T12
Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered.
Summary for 8T12
Entry DOI | 10.2210/pdb8t12/pdb |
EMDB information | 40952 |
Descriptor | Signal transducer and activator of transcription 2, Non-structural protein 5, ZINC ION (3 entities in total) |
Functional Keywords | complex, immune system-viral protein complex, immune system/viral protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 201420.51 |
Authors | Biswal, M.,Lu, J.,Song, J. (deposition date: 2023-06-01, release date: 2024-01-17, Last modification date: 2024-07-31) |
Primary citation | Biswal, M.,Yao, W.,Lu, J.,Chen, J.,Morrison, J.,Hai, R.,Song, J. A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition. Commun Biol, 7:76-76, 2024 Cited by PubMed: 38195857DOI: 10.1038/s42003-024-05768-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.34 Å) |
Structure validation
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