8T12

Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0001932	biological_process	regulation of protein phosphorylation
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006952	biological_process	defense response
A	0007165	biological_process	signal transduction
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0042127	biological_process	regulation of cell population proliferation
A	0042802	molecular_function	identical protein binding
A	0043434	biological_process	response to peptide hormone
A	0044389	molecular_function	ubiquitin-like protein ligase binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051607	biological_process	defense response to virus
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
A	0070721	cellular_component	ISGF3 complex
A	0090140	biological_process	regulation of mitochondrial fission
A	0090575	cellular_component	RNA polymerase II transcription regulator complex
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0004483	molecular_function	methyltransferase cap1 activity
B	0005524	molecular_function	ATP binding
B	0008168	molecular_function	methyltransferase activity
B	0032259	biological_process	methylation
B	0039694	biological_process	viral RNA genome replication

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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