8VOJ

The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6

This is a non-PDB format compatible entry.

Summary for 8VOJ

• Entry DOI: 10.2210/pdb8voj/pdb
• EMDB information: 43386
• Descriptor: Isoform 2 of Kelch repeat and BTB domain-containing protein 4, Histone deacetylase 1, REST corepressor 1, ... (6 entities in total)
• Functional Keywords: molecular glue, protein degradation, e3 ligase, transcription and translation, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 222275.76

Authors

Xie, X.,Mao, H.,Liau, B.,Zheng, N. (deposition date: 2024-01-15, release date: 2024-12-04)

• Primary citation: Zheng, N.,Xie, X.,Liau, B.; Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.77 Å)