8VOJ
The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 2 of Kelch repeat and BTB domain-containing protein 4 | polymer | 534 | 59971.7 | 2 | UniProt (Q9NVX7) Pfam (PF00651) Pfam (PF07707) Pfam (PF07646) | Homo sapiens (human) | BTB and kelch domain-containing protein 4 |
| 2 | C (C) | Histone deacetylase 1 | polymer | 482 | 55178.9 | 1 | UniProt (Q13547) Pfam (PF00850) | Homo sapiens (human) | HD1,Protein deacetylase HDAC1,Protein decrotonylase HDAC1 |
| 3 | D (D) | REST corepressor 1 | polymer | 401 | 45974.4 | 1 | UniProt (Q9UKL0) Pfam (PF01448) Pfam (PF00249) Pfam (PF20878) | Homo sapiens (human) | Protein CoREST |
| 4 | E (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | Homo sapiens | ||
| 5 | F (C) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 6 | G (C) | (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine | non-polymer | 453.5 | 1 | Chemie (A1ACV) |
Sequence modifications
D: -18 - 381 (UniProt: Q9UKL0)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 221096.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1179.0 | |
| All* | Total formula weight | 222275.8 |
