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4LQF	Structure of murine IgG2b A2C7-Fab in complex with vaccinia antigen A33R at the resolution of 2.3 Angstroms Descriptor: A33R, Murine IgG2b A2C7 Heavy chain Fab domain, Murine IgG2b A2C7 Light chain Fab domain, ... Authors: Matho, M.H, Schlossman, A.M, Zajonc, D.M. Deposit date: 2013-07-17 Release date: 2014-08-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer. Plos Pathog., 11, 2015
4LRI	Anti CMV Fab Fragment Descriptor: MSL-109 Heavy Chain, MSL-109 Light Chain Authors: Stengel, K.F. Deposit date: 2013-07-19 Release date: 2014-05-21 Last modified: 2014-07-02 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109. Proc.Natl.Acad.Sci.USA, 111, 2014
4ACP	Deactivation of human IgG1 Fc by endoglycosidase treatment Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, IG GAMMA-1 CHAIN C REGION Authors: Raman, K, Bowden, T.A, Krishna, B.A, Dwek, R.A, Crispin, M, Scanlan, C.N. Deposit date: 2011-12-16 Release date: 2012-04-25 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Selective Deactivation of Serum Igg: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions. J.Mol.Biol., 420, 2012
7XW7	TSHR-K1-70 complex Descriptor: K1-70 scFv, Thyrotropin receptor Authors: Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. Deposit date: 2022-05-26 Release date: 2022-08-17 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.5 Å) Cite: Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
7XW5	TSHR-thyroid stimulating hormone-Gs-ML109 complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ... Authors: Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. Deposit date: 2022-05-26 Release date: 2022-08-24 Last modified: 2022-10-05 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
7PNM	Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 46C12 antibody Fab fragment Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 46C12 antibody heavy chain, ... Authors: Hurdiss, D.L. Deposit date: 2021-09-07 Release date: 2022-04-20 Last modified: 2022-11-09 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Nat Commun, 13, 2022
7PO5	Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 47C9 antibody Fab fragment Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 47C9 antibody heavy chain, 47C9 antibody light chain, ... Authors: Hurdiss, D.L. Deposit date: 2021-09-08 Release date: 2022-04-20 Last modified: 2022-11-09 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Nat Commun, 13, 2022
7PNQ	Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 43E6 antibody Fab fragment Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 43E6 antibody heavy chain, 43E6 antibody light chain, ... Authors: Hurdiss, D.L. Deposit date: 2021-09-07 Release date: 2022-04-20 Last modified: 2022-11-09 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Nat Commun, 13, 2022
7NKS	Structure of the Hantaan virus Gn glycoprotein ectodomain in complex with Fab HTN-Gn1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, Fab HTN-Gn1 heavy chain, ... Authors: Rissanen, I, Bowden, T.A, Huiskonen, J.T, Stass, R. Deposit date: 2021-02-18 Release date: 2021-06-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen. Mbio, 12, 2021
8F0L	Crystal Structure of the Human T cell Receptor CD3(EPSILON) N-Terminal Peptide Complexed with ADI-26906 FAB Descriptor: ADI-26906 Fab Heavy Chain, ADI-26906 Fab Light Chain, GLYCEROL, ... Authors: Battles, M.B, Welin, M. Deposit date: 2022-11-03 Release date: 2023-03-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Structure-based engineering of a novel CD3 epsilon-targeting antibody for reduced polyreactivity. Mabs, 15, 2023
5OBF	fAb. AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery. Descriptor: GLYCEROL, SULFATE ION, fAb Heavy chain, ... Authors: Vicentini, G, Convery, M.A. Deposit date: 2017-06-26 Release date: 2017-11-08 Method: X-RAY DIFFRACTION (1.92 Å) Cite: AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery To Be Published
5OB5	fAb complex with GroBeta. AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery. Descriptor: C-X-C motif chemokine 2, GLYCEROL, SULFATE ION, ... Authors: Zhao, B, Ward, P, Convery, M.A. Deposit date: 2017-06-26 Release date: 2017-11-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery To Be Published
7O9S	Hantaan virus Gn in complex with Fab nnHTN-Gn2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, Fab nnHTN-Gn2 Heavy chain, ... Authors: Rissanen, I, Bowden, T.A, Huiskonen, J.T, Stass, R. Deposit date: 2021-04-16 Release date: 2021-06-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen. Mbio, 12, 2021
6XZW	Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab. Descriptor: 1,2-ETHANEDIOL, Fab 4B3 (heavy chain), Fab 4B3 (light chain), ... Authors: Veggi, D, Cozzi, R. Deposit date: 2020-02-05 Release date: 2020-10-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: 4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp. Plos Pathog., 16, 2020
2DDQ	Crystal Structure of the Fab fragment of a R310 antibody complexed with (R)-HNE-histidine adduct Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-ACETYL-1-[(2R,3S,5R)-5-HYDROXY-2-PENTYLTETRAHYDROFURAN-3-YL]-L-HISTIDINE, R310 antibody heavy chain, ... Authors: Ito, S. Deposit date: 2006-02-02 Release date: 2006-07-11 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Bispecific abs against modified protein and DNA with oxidized lipids Proc.Natl.Acad.Sci.Usa, 103, 2006
6U8K	Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV3 Descriptor: Heavy chain of Fab HCV3, JIIIabc RNA (68-MER), Light chain of Fab HCV3 Authors: Koirala, D, Lewicka, A, Koldobskaya, Y, Huang, H, Piccirilli, J.A. Deposit date: 2019-09-05 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. Acs Chem.Biol., 15, 2020
8HS2	Orphan GPR20 in complex with Fab046 Descriptor: Light chain of Fab046, Soluble cytochrome b562,G-protein coupled receptor 20, heavy chain of Fab046 Authors: Lin, X, Jiang, S, Xu, F. Deposit date: 2022-12-16 Release date: 2023-03-08 Last modified: 2023-03-15 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
8HS3	Gi bound orphan GPR20 in ligand-free state Descriptor: Ggama, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Lin, X, Jiang, S, Xu, F. Deposit date: 2022-12-16 Release date: 2023-03-08 Last modified: 2023-03-15 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
8HSC	Gi bound Orphan GPR20 complex with Fab046 in ligand-free state Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Lin, X, Jiang, S, Xu, F. Deposit date: 2022-12-19 Release date: 2023-03-08 Last modified: 2023-03-15 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
6U8D	Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV2 Descriptor: Heavy chain of Fab HCV2, JIIIabc RNA (68-MER), Light chain of Fab HCV2 Authors: Koirala, D, Lewicka, A, Koldobskaya, Y, Huang, H, Piccirilli, J.A. Deposit date: 2019-09-04 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.807 Å) Cite: Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. Acs Chem.Biol., 15, 2020
7ZBU	CryoEM structure of SARS-CoV-2 spike monomer in complex with neutralising antibody P008_60 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-2-[[5-[(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, P008_60 antibody, ... Authors: Rosa, A, Pye, V.E, Cronin, N, Cherepanov, P. Deposit date: 2022-03-24 Release date: 2022-08-17 Last modified: 2022-08-31 Method: ELECTRON MICROSCOPY (4.31 Å) Cite: A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination. Cell Rep, 40, 2022
7RU8	CC6.30 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (RBD/Fv local refinement) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC6.30 Fab Kappa chain Fv, ... Authors: Ozorowski, G, Turner, H.L, Ward, A.B. Deposit date: 2021-08-16 Release date: 2022-08-24 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways. Iscience, 25, 2022
7RU3	CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Ozorowski, G, Turner, H.L, Ward, A.B. Deposit date: 2021-08-16 Release date: 2022-08-24 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways. Iscience, 25, 2022
5NPH	Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the Fab fragment of the non-neutralizing antibody DAO5 Descriptor: Genome polyprotein, Heavy chain of Fab fragment derived from non-neutralizing antibody DAO5, Light chain of Fab fragment derived from non-neutralizing antibody DAO5 Authors: Vasiliauskaite, I, Rey, F.A, Krey, T. Deposit date: 2017-04-16 Release date: 2017-05-24 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8, 2017
7RU5	CC6.30 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC6.30 Fab heavy chain Fv, ... Authors: Ozorowski, G, Turner, H.L, Ward, A.B. Deposit date: 2021-08-16 Release date: 2022-08-24 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways. Iscience, 25, 2022

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