4ACP

Deactivation of human IgG1 Fc by endoglycosidase treatment

Summary for 4ACP

• Entry DOI: 10.2210/pdb4acp/pdb
• Related: 1AJ7 1AQK 1BEY 1D5B 1D5I 1D6V 1DN2 1E4K 1FC1 1FC2 1FCC 1H3T 1H3U 1H3V 1H3W 1H3Y 1I7Z 1L6X 1OQX 1T83 1T89 2IWG 2J6E 2RCS 2WAH
• Descriptor: IG GAMMA-1 CHAIN C REGION, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: immune system, igg, antibody, kifunensine
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Secreted: P01857
• Total number of polymer chains: 2
• Total formula weight: 54252.26

Authors

Raman, K.,Bowden, T.A.,Krishna, B.A.,Dwek, R.A.,Crispin, M.,Scanlan, C.N. (deposition date: 2011-12-16, release date: 2012-04-25, Last modification date: 2023-12-20)

• Primary citation: Baruah, K.,Bowden, T.A.,Krishna, B.A.,A Dwek, R.,Crispin, M.,Scanlan, C.N.; Selective Deactivation of Serum Igg: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions.; J.Mol.Biol., 420:1-, 2012; PubMed: 22484364; DOI: 10.1016/J.JMB.2012.04.002

Experimental method

X-RAY DIFFRACTION (2.49 Å)