4ACP
Deactivation of human IgG1 Fc by endoglycosidase treatment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | IG GAMMA-1 CHAIN C REGION | polymer | 240 | 27015.5 | 2 | UniProt (P01857) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | HUMAN IG GAMMA-1 CHAIN C REGION |
| 2 | C (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A, B: 218 - 446 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Gly 216 | - | expression tag |
| Thr 217 | - | expression tag |
| Gly 447 | - | expression tag |
| Thr 448 | - | expression tag |
| Lys 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
| Ala 393 | Thr 276 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54031.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 54252.3 |
