1L6X

FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B-DOMAIN FROM PROTEIN A CALLED Z34C

Summary for 1L6X

• Entry DOI: 10.2210/pdb1l6x/pdb
• Related: 1DN2
• Descriptor: IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN CONSTANT REGION, Minimized B-domain of Protein A Z34C, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: igg1 fc, protein a, fc complex, b-domain, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 29525.91

Authors

Idusogie, E.E.,Presta, L.G.,Santoro-Gazzano, H.,Totpal, K.,Wong, P.Y.,Ultsch, M.,Meng, Y.G.,Mullkerrin, M.G. (deposition date: 2002-03-14, release date: 2002-04-10, Last modification date: 2023-08-16)

• Primary citation: Idusogie, E.E.,Presta, L.G.,Gazzano-Santoro, H.,Totpal, K.,Wong, P.Y.,Ultsch, M.,Meng, Y.G.,Mulkerrin, M.G.; Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc.; J.Immunol., 164:4178-4184, 2000; PubMed: 10754313

Experimental method

X-RAY DIFFRACTION (1.65 Å)