6U8K

Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV3

Summary for 6U8K

Entry DOI	10.2210/pdb6u8k/pdb
Descriptor	JIIIabc RNA (68-MER), Heavy chain of Fab HCV3, Light chain of Fab HCV3, ... (4 entities in total)
Functional Keywords	internal ribosome entry site (ires), hepatitis c virus, junction iiiabc, antibody-assisted rna crystallography, viral translation, viral rna domains, rna, rna-immune system complex, rna/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	9
Total formula weight	210370.75
Authors	Koirala, D.,Lewicka, A.,Koldobskaya, Y.,Huang, H.,Piccirilli, J.A. (deposition date: 2019-09-05, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citation	Koirala, D.,Lewicka, A.,Koldobskaya, Y.,Huang, H.,Piccirilli, J.A. Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. Acs Chem.Biol., 15:205-216, 2020 Cited by PubMed: 31765566 DOI: 10.1021/acschembio.9b00785 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation