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3MG0	Structure of yeast 20S proteasome with bortezomib Descriptor: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, Proteasome component C1, Proteasome component C11, ... Authors: Sintchak, M.D. Deposit date: 2010-04-05 Release date: 2011-05-18 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit. Biochem.J., 430, 2010
7SGJ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-711 Descriptor: 1,2-ETHANEDIOL, 4-[(3-anilino-3-oxopropyl)(methyl)amino]-N-hydroxybutanamide, DI(HYDROXYETHYL)ETHER, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGI	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14 Descriptor: 5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGG	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with SAHA Descriptor: DI(HYDROXYETHYL)ETHER, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, PHOSPHATE ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGK	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-728 Descriptor: N-(2-{[4-(hydroxyamino)-4-oxobutyl](methyl)amino}ethyl)benzamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
8A1S	Structure of murine perforin-2 (Mpeg1) pore in twisted form Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein Authors: Yu, X, Ni, T, Zhang, P, Gilbert, R. Deposit date: 2022-06-02 Release date: 2022-07-20 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (4 Å) Cite: Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. Embo J., 41, 2022
8A1D	Structure of murine perforin-2 (Mpeg1) pore in ring form Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein Authors: Yu, X, Ni, T, Zhang, P, Gilbert, R. Deposit date: 2022-06-01 Release date: 2022-07-20 Last modified: 2022-12-14 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. Embo J., 41, 2022
7S3V	Structure of HsKYNase_66, an evolved variant of human kynureninase with greatly increased activity towards kynurenine Descriptor: Kynureninase Authors: Burkholder, N.T, Zhang, Y.J. Deposit date: 2021-09-08 Release date: 2022-12-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.249 Å) Cite: Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme. Nat Catal, 5, 2022
8AJ7	Kunitz domain of Amblyomin-X Descriptor: 1,2-ETHANEDIOL, Kunitz domain of Amblyomin-X Authors: Ciccone, L, Servent, D, Stura, E.A. Deposit date: 2022-07-27 Release date: 2023-02-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity. Front Mol Biosci, 10, 2023
7U6B	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Indolethyl Piperidine-4-acrylhydroxamic Acid Inhibitor Descriptor: (2E)-N-hydroxy-3-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}prop-2-enamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-03-03 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234, 2022
7U59	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Piperidine-4-hydroxamic acid Inhibitor Descriptor: 1,2-ETHANEDIOL, 1-[2-(benzylamino)ethyl]-N-hydroxypiperidine-4-carboxamide, PHOSPHATE ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-03-01 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.18 Å) Cite: First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement. Chembiochem, 23, 2022
7V1N	Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI Descriptor: Isoform Beta of Tissue factor pathway inhibitor, Toxin B Authors: Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L. Deposit date: 2021-08-05 Release date: 2022-02-23 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 185, 2022
7ZQS	Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (30-MER), ... Authors: Bansia, H, Wang, T, Gutierrez, D, des Georges, A. Deposit date: 2022-05-02 Release date: 2022-08-17 Method: ELECTRON MICROSCOPY (2.54 Å) Cite: Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing. J.Am.Chem.Soc., 144, 2022
7U69	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Phenethyl Piperidine-4-acrylhydroxamic Acid Inhibitor Descriptor: (2E)-N-hydroxy-3-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-03-03 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234, 2022
7U3M	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with N-methylpiperazine Benzhydroxamic Acid Descriptor: N-hydroxy-4-[(4-methylpiperazin-1-yl)methyl]benzamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-02-27 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234, 2022
7U6A	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 3-thienylmethyl Benzhydroxamic Acid Inhibitor Descriptor: 1,2-ETHANEDIOL, N-hydroxy-4-({[(thiophen-3-yl)methyl]amino}methyl)benzamide, PHOSPHATE ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-03-03 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234, 2022
7VOO	Induced alpha-2-macroglobulin monomer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Huang, X, Wang, Y, Ping, Z. Deposit date: 2021-10-14 Release date: 2022-10-19 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
8VC3	Voltage gated potassium ion channel Kv1.2 in complex with DTx Descriptor: Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2 Authors: Wu, Y, Sigworth, F.J. Deposit date: 2023-12-13 Release date: 2024-07-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting. Biorxiv, 2024
8WVB	Crystal structure of Lsd18 mutant S195M Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Putative epoxidase LasC Authors: Liu, N, Xiao, H.L, Chen, X. Deposit date: 2023-10-23 Release date: 2023-12-13 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A. Int J Mol Sci, 24, 2023
8WVF	Crystal structure of Lsd18 mutant T189M and S195M Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Putative epoxidase LasC Authors: Liu, N, Xiao, H.L, Chen, X. Deposit date: 2023-10-23 Release date: 2023-12-13 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.757 Å) Cite: Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A. Int J Mol Sci, 24, 2023
7VON	Native alpha-2-macroglobulin monomer Descriptor: Alpha-2-macroglobulin Authors: Huang, X, Wang, Y. Deposit date: 2021-10-14 Release date: 2022-11-16 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
3S93	Crystal structure of conserved motif in TDRD5 Descriptor: Tudor domain-containing protein 5, UNKNOWN ATOM OR ION Authors: Chao, X, Tempel, W, Bian, C, Kania, J, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2011-05-31 Release date: 2011-08-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Crystal structure of conserved motif in TDRD5 to be published
4QQG	Crystal structure of an N-terminal HTATIP fragment Descriptor: Histone acetyltransferase KAT5, UNKNOWN ATOM OR ION Authors: Liu, Y, Tempel, W, Wernimont, A.K, Dobrovetsky, E, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2014-06-27 Release date: 2014-07-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and histone binding studies of the chromo barrel domain of TIP60. FEBS Lett., 592, 2018
6U7R	NMR solution structure of SFTI1 based KLK7 protease inhibitor Descriptor: GLY-LYS-CYS-LEU-PHE-SER-ASN-PRO-PRO-ILE-CYS-PHE-PRO-ASN inhibitor Authors: White, A.M, Harvey, P.J, Durek, T, Craik, D.J. Deposit date: 2019-09-03 Release date: 2020-04-22 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angew.Chem.Int.Ed.Engl., 59, 2020
4TLV	CARDS TOXIN, NICKED Descriptor: ACETATE ION, ADP-ribosylating toxin CARDS, GLYCEROL, ... Authors: Taylor, A.B, Pakhomova, O.N, Hart, P.J. Deposit date: 2014-05-30 Release date: 2015-04-08 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae. Proc.Natl.Acad.Sci.USA, 112, 2015

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