Structure of yeast 20S proteasome with bortezomib

Summary for 3MG0

Related3MG4 3MG6 3MG7 3MG8
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (16 entities in total)
Functional Keywords20s proteasome, hydrolase
Biological sourceSaccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight706511.66
Sintchak, M.D. (deposition date: 2010-04-05, release date: 2011-05-18, Last modification date: 2017-11-08)
Primary citation
Blackburn, C.,Gigstad, K.M.,Hales, P.,Garcia, K.,Jones, M.,Bruzzese, F.J.,Barrett, C.,Liu, J.X.,Soucy, T.A.,Sappal, D.S.,Bump, N.,Olhava, E.J.,Fleming, P.,Dick, L.R.,Tsu, C.,Sintchak, M.D.,Blank, J.L.
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem.J., 430:461-476, 2010
PubMed: 20632995 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20100383
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24790.4%5.3%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16