3MG0
Structure of yeast 20S proteasome with bortezomib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O | Proteasome component Y7 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit Y7, Multicatalytic endopeptidase complex subunit Y7, Proteinase YSCE subunit 7 |
| 2 | B, P | Proteasome component Y13 | polymer | 244 | 27050.4 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit Y13, Multicatalytic endopeptidase complex subunit Y13, Proteinase YSCE subunit 13 |
| 3 | C, Q | Proteasome component PRE6 | polymer | 241 | 26903.3 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6, Proteinase YSCE subunit PRE6 |
| 4 | D, R | Proteasome component PUP2 | polymer | 242 | 26544.8 | 2 | UniProt (P32379) Pfam (PF00227) Pfam (PF10584) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2, Proteinase YSCE subunit PUP2 |
| 5 | E, S | Proteasome component PRE5 | polymer | 233 | 25502.8 | 2 | UniProt (P40302) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5, Proteinase YSCE subunit PRE5 |
| 6 | F, T | Proteasome component C1 | polymer | 244 | 26892.5 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit C1, Multicatalytic endopeptidase complex subunit C1, Proteinase YSCE subunit 1 |
| 7 | G, U | Proteasome component C7-alpha | polymer | 243 | 27316.0 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit C7-alpha, Multicatalytic endopeptidase complex C7, Proteasome component Y8, Proteinase YSCE subunit 7, SCL1 suppressor protein |
| 8 | H, V | Proteasome component PUP1 | polymer | 222 | 23987.3 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1, Proteinase YSCE subunit PUP1 |
| 9 | I, W | Proteasome component PUP3 | polymer | 204 | 22496.6 | 2 | UniProt (P25451) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3 |
| 10 | J, X | Proteasome component C11 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit C11, Multicatalytic endopeptidase complex subunit C11, Proteinase YSCE subunit 11 |
| 11 | K, Y | Proteasome component PRE2 | polymer | 212 | 23325.2 | 2 | UniProt (P30656) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2, Proteinase YSCE subunit PRE2 |
| 12 | L, Z | Proteasome component C5 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Multicatalytic endopeptidase complex subunit C5 |
| 13 | M, 1 | Proteasome component PRE4 | polymer | 233 | 25945.5 | 2 | UniProt (P30657) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4, Proteinase YSCE subunit PRE4 |
| 14 | N, 2 | Proteasome component PRE3 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast) | Macropain subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3, Proteinase YSCE subunit PRE3 |
| 15 | H, K, N, V, Y... | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | non-polymer | 384.2 | 6 | Chemie (BO2) | |||
| 16 | water | water | 18.0 | 1037 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 704206.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2305.4 | |
| All* | Total formula weight | 706511.7 |
