7V1N

Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI

Summary for 7V1N

• Entry DOI: 10.2210/pdb7v1n/pdb
• EMDB information: 31628
• Descriptor: Toxin B, Isoform Beta of Tissue factor pathway inhibitor (2 entities in total)
• Functional Keywords: tcdb4, tfpi, receptor, complex, toxin
• Biological source: Clostridioides difficile (Peptoclostridium difficile); More
• Total number of polymer chains: 2
• Total formula weight: 299135.63

Authors

Luo, J.,Yang, Q.,Zhang, X.,Zhang, Y.,Wan, L.,Li, Y.,Tao, L. (deposition date: 2021-08-05, release date: 2022-02-23, Last modification date: 2022-03-30)

• Primary citation: Luo, J.,Yang, Q.,Zhang, X.,Zhang, Y.,Wan, L.,Zhan, X.,Zhou, Y.,He, L.,Li, D.,Jin, D.,Zhen, Y.,Huang, J.,Li, Y.,Tao, L.; TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.; Cell, 185:980-994.e15, 2022; PubMed: 35303428; DOI: 10.1016/j.cell.2022.02.010

Experimental method

ELECTRON MICROSCOPY (3.2 Å)