Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7V1N

Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008289	molecular_function	lipid binding
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0020002	cellular_component	host cell plasma membrane
A	0035821	biological_process	modulation of process of another organism
A	0044164	cellular_component	host cell cytosol
A	0044175	cellular_component	host cell endosome membrane
A	0046872	molecular_function	metal ion binding
A	0090729	molecular_function	toxin activity
K	0004867	molecular_function	serine-type endopeptidase inhibitor activity
K	0005576	cellular_component	extracellular region
K	0010466	biological_process	negative regulation of peptidase activity
K	0030414	molecular_function	peptidase inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FiyGGCegnqnrFesleeC

Chain	Residue	Details
K	PHE82-CYS100
K	PHE153-CYS171

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	373
Details	Domain: {"description":"GT44","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	207
Details	Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Repeat: {"description":"Cell wall-binding 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	22
Details	Repeat: {"description":"Cell wall-binding 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 18","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 19","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	89
Details	Region: {"description":"Four-helical bundle","evidences":[{"source":"UniProtKB","id":"Q46342","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	373
Details	Region: {"description":"Glucosyltransferase region","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	255
Details	Region: {"description":"Autoprocessing region","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	32
Details	Region: {"description":"Interaction with host frizzled receptors FZD1, FZD2 and FZD7","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	532
Details	Region: {"description":"Receptor-binding (CROPS) region","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	1
Details	Active site: {"description":"For protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Active site: {"description":"Nucleophile; for protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P16154","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	1
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"15632438","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	50
Details	Domain: {"description":"BPTI/Kunitz inhibitor 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	1
Details	Site: {"description":"Reactive bond"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19017259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8639592","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)