7V1N

Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Toxin B	polymer	2375	270454.0	1	UniProt (Q9EXR0) Pfam (PF11647) Pfam (PF01473) Pfam (PF19127) Pfam (PF12918) Pfam (PF12919) Pfam (PF11713) Pfam (PF12920)	Clostridioides difficile (Peptoclostridium difficile)
2	B (K)	Isoform Beta of Tissue factor pathway inhibitor	polymer	251	28681.6	1	UniProt (P10646) Pfam (PF00014)	Homo sapiens (Human)	TFPI,Extrinsic pathway inhibitor,EPI,Lipoprotein-associated coagulation inhibitor,LACI

Sequence modifications

A: 1 - 2367 (UniProt: Q9EXR0)

PDB	External Database	Details
Asp 366	Gly 366	conflict
Asn 385	Asp 385	conflict
Ile 680	Leu 680	conflict
Lys 1211	Glu 1211	conflict
Leu 1528	Ile 1528	conflict
Ser 1618	Phe 1618	conflict
Ile 1693	Val 1693	conflict
Asn 1697	Gly 1697	conflict
Ala 1874	Pro 1874	conflict
Lys 2016	Arg 2016	conflict
Thr 2229	Ala 2229	conflict
His 2368	-	expression tag
His 2369	-	expression tag
His 2370	-	expression tag
His 2371	-	expression tag
His 2372	-	expression tag
His 2373	-	expression tag
His 2374	-	expression tag
His 2375	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	299135.6
All*	Total formula weight	299135.6

*Water molecules are not included.