7U59
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Piperidine-4-hydroxamic acid Inhibitor
Summary for 7U59
Entry DOI | 10.2210/pdb7u59/pdb |
Descriptor | Polyamine deacetylase HDAC10, 1,2-ETHANEDIOL, 1-[2-(benzylamino)ethyl]-N-hydroxypiperidine-4-carboxamide, ... (8 entities in total) |
Functional Keywords | histone deacetylase, hydrolase |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 1 |
Total formula weight | 75983.71 |
Authors | Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2022-03-01, release date: 2023-01-11, Last modification date: 2023-10-25) |
Primary citation | Herp, D.,Ridinger, J.,Robaa, D.,Shinsky, S.A.,Schmidtkunz, K.,Yesiloglu, T.Z.,Bayer, T.,Steimbach, R.R.,Herbst-Gervasoni, C.J.,Merz, A.,Romier, C.,Sehr, P.,Gunkel, N.,Miller, A.K.,Christianson, D.W.,Oehme, I.,Sippl, W.,Jung, M. First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement. Chembiochem, 23:e202200180-e202200180, 2022 Cited by PubMed: 35608330DOI: 10.1002/cbic.202200180 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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