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4GE6	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7 Descriptor: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GFU	PTPN18 in complex with HER2-pY1248 phosphor-peptides Descriptor: HER2-pY1248 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. Deposit date: 2012-08-04 Release date: 2013-08-07 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2 Å) Cite: PTPN18-HER2 peptides To be Published
4GFV	PTPN18 in complex with HER2-pY1196 phosphor-peptides Descriptor: HER2-pY1196 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. Deposit date: 2012-08-04 Release date: 2013-10-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.095 Å) Cite: PTPN18-HER2 peptides To be Published
4GRZ	Crystal structure of SHP1 catalytic domain with PO4 Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.3732 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4GS0	Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide Descriptor: Tyrosine-protein kinase JAK1, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7961 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4GRY	Crystal structure of SHP1 catalytic domain with SO4 Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6998 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4GWF	Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. Deposit date: 2012-09-03 Release date: 2013-09-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation TO BE PUBLISHED
4H1O	Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation Descriptor: 1,2-ETHANEDIOL, Tyrosine-protein phosphatase non-receptor type 11 Authors: Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. Deposit date: 2012-09-11 Release date: 2013-09-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation To be Published
4H34	Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 Authors: Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. Deposit date: 2012-09-13 Release date: 2013-10-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation To be Published
4HJQ	SHP-1 catalytic domain WPD loop closed Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Boggon, T.J. Deposit date: 2012-10-13 Release date: 2013-04-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8013 Å) Cite: SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States. Protein Pept.Lett., 20, 2013
4HJP	SHP-1 catalytic domain WPD loop open Descriptor: Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Boggon, T.J. Deposit date: 2012-10-13 Release date: 2013-04-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.3994 Å) Cite: SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States. Protein Pept.Lett., 20, 2013
4I8N	CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID Descriptor: Tyrosine-protein phosphatase non-receptor type 1, [(4-{(2S)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid Authors: Reddy, S.M.V.V.V, Rao, K.N, Subramanya, H. Deposit date: 2012-12-03 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor. Protein Pept.Lett., 21, 2014
4ICZ	HER2 1221/1222 phosphorylation regulated by PTPN9 Descriptor: HER2, Tyrosine-protein phosphatase non-receptor type 9 Authors: Xu, Y.F, Wang, H.M, Liu, C.H, Yu, X, Sun, J.P. Deposit date: 2012-12-11 Release date: 2013-12-11 Method: X-RAY DIFFRACTION (1.9 Å) Cite: HER2 1221/1222 phosphorylation regulated by PTPN9 To be Published
4IKC	Crystal Structure of catalytic domain of PTPRQ Descriptor: CHLORIDE ION, Phosphotidylinositol phosphatase PTPRQ, SULFATE ION Authors: Yu, K.R, Ryu, S.E, Kim, S.J. Deposit date: 2012-12-26 Release date: 2013-07-31 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates Acta Crystallogr.,Sect.D, 69, 2013
3ZM1	Catalytic domain of human SHP2 Descriptor: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 Authors: Bohm, K, Schuetz, A, Roske, Y, Heinemann, U. Deposit date: 2013-02-04 Release date: 2014-04-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10, 2015
3ZM0	Catalytic domain of human SHP2 Descriptor: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 Authors: Bohm, K, Schuetz, A, Roske, Y, Heinemann, U. Deposit date: 2013-02-04 Release date: 2014-04-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10, 2015
3ZM2	Catalytic domain of human SHP2 Descriptor: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 Authors: Bohm, K, Schuetz, A, Roske, Y, Heinemann, U. Deposit date: 2013-02-04 Release date: 2014-04-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10, 2015
3ZM3	Catalytic domain of human SHP2 Descriptor: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 Authors: Bohm, K, Schuetz, A, Roske, Y, Heinemann, U. Deposit date: 2013-02-04 Release date: 2014-04-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10, 2015
4J51	Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04 Descriptor: 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 22 Authors: Liu, D, He, Y, Zhang, Z.-Y. Deposit date: 2013-02-07 Release date: 2013-07-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases. J.Med.Chem., 56, 2013
3ZMQ	Src-derived mutant peptide inhibitor complex of PTP1B Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 Authors: Temmerman, K, Pogenberg, V, Meyer, C, Koehn, M, Wilmanns, M. Deposit date: 2013-02-12 Release date: 2014-01-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Development of Accessible Peptidic Tool Compounds to Study the Phosphatase Ptp1B in Intact Cells. Acs Chem.Biol., 9, 2014
3ZMP	Src-derived peptide inhibitor complex of PTP1B Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 Authors: Temmerman, K, Pogenberg, V, Meyer, C, Koehn, M, Wilmanns, M. Deposit date: 2013-02-12 Release date: 2014-01-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.619 Å) Cite: Development of Accessible Peptidic Tool Compounds to Study the Phosphatase Ptp1B in Intact Cells. Acs Chem.Biol., 9, 2014
4BJO	Nitrate in the active site of PTP1b is a putative mimetic of the transition state Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... Authors: Kenny, P.W, Newman, J, Peat, T.S. Deposit date: 2013-04-19 Release date: 2014-02-12 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Nitrate in the Active Site of Protein Tyrosine Phosphatase 1B is a Putative Mimetic of the Transition State. Acta Crystallogr.,Sect.D, 70, 2014
4BPC	Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form Descriptor: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S Authors: Jeon, T.J, Chien, P.N, Chun, H.J, Ryu, S.E. Deposit date: 2013-05-24 Release date: 2013-07-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form Mol.Cells, 36, 2013
2MBC	Solution Structure of human holo-PRL-3 in complex with vanadate Descriptor: Protein tyrosine phosphatase type IVA 3 Authors: Jeong, K, Kang, D, Kim, J, Shin, S, Jin, B, Lee, C, Kim, E, Jeon, Y.H, Kim, Y. Deposit date: 2013-07-29 Release date: 2013-10-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure and backbone dynamics of vanadate-bound PRL-3: comparison of 15N nuclear magnetic resonance relaxation profiles of free and vanadate-bound PRL-3. Biochemistry, 53, 2014
4NND	Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Descriptor: Receptor tyrosine-protein kinase erbB-2, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H, Yang, F, Yang, D, Du, Y. Deposit date: 2013-11-17 Release date: 2014-11-19 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites To be Published

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