4NND

Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites

Summary for 4NND

DescriptorTyrosine-protein phosphatase non-receptor type 18, Receptor tyrosine-protein kinase erbB-2 (3 entities in total)
Functional Keywordsbeta barrel, beta-propeller, kinase binding, phosphorylation, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationNucleus  Q99952
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm P04626
Total number of polymer chains8
Total molecular weight135814.81
Authors
Wang, H.,Yang, F.,Yang, D.,Du, Y. (deposition date: 2013-11-17, release date: 2014-11-19)
Primary citation
Wang, H.,Yang, F.,Yang, D.,Du, Y.
Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
To be Published,
Experimental method
X-RAY DIFFRACTION (2.502 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27981.1%7.7%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution