4NND
Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, B, D, G) | Tyrosine-protein phosphatase non-receptor type 18 | polymer | 290 | 33077.9 | 4 | UniProt (Q99952) Pfam (PF00102) | Homo sapiens (human) | Brain-derived phosphatase |
| 2 | B, D, F, H (F, C, E, H) | Receptor tyrosine-protein kinase erbB-2 | polymer | 6 | 875.8 | 4 | UniProt (P04626) | Homo sapiens | Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2 |
| 3 | I, J, K, L, M (A, B, D, G, H) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A, B, D, G: 6 - 295 (UniProt: Q99952)
| PDB | External Database | Details |
|---|---|---|
| Ser 229 | Cys 229 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 135814.8 | |
| All* | Total formula weight | 135814.8 |
