4NND
Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| D | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| D | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| D | 0006470 | biological_process | protein dephosphorylation |
| D | 0016311 | biological_process | dephosphorylation |
| G | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| G | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| G | 0006470 | biological_process | protein dephosphorylation |
| G | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
| Chain | Residue |
| B | TYR62 |
| B | CYS233 |
| B | GLY234 |
| B | ARG235 |
| B | GLN276 |
| B | LYS63 |
| B | ASP64 |
| B | ASP197 |
| B | ARG198 |
| B | SER229 |
| B | SER230 |
| B | ALA231 |
| B | GLY232 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
| Chain | Residue |
| D | TYR62 |
| D | LYS63 |
| D | ASP64 |
| D | ARG140 |
| D | ASP197 |
| D | ARG198 |
| D | SER229 |
| D | SER230 |
| D | ALA231 |
| D | GLY232 |
| D | CYS233 |
| D | GLY234 |
| D | ARG235 |
| D | GLN276 |
| D | HOH301 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
| Chain | Residue |
| A | TYR62 |
| A | LYS63 |
| A | ASP64 |
| A | ASP197 |
| A | ARG198 |
| A | SER229 |
| A | SER230 |
| A | ALA231 |
| A | GLY232 |
| A | CYS233 |
| A | GLY234 |
| A | ARG235 |
| A | GLN276 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
| Chain | Residue |
| G | TYR62 |
| G | LYS63 |
| G | ASP64 |
| G | VAL65 |
| G | ARG138 |
| G | ASP197 |
| G | ARG198 |
| G | SER229 |
| G | SER230 |
| G | ALA231 |
| G | GLY232 |
| G | CYS233 |
| G | GLY234 |
| G | ARG235 |
| G | GLN276 |
| G | HOH301 |
| H | HOH201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 265 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
