4NND
Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
A | 0006470 | biological_process | protein dephosphorylation |
A | 0016311 | biological_process | dephosphorylation |
B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
B | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
B | 0006470 | biological_process | protein dephosphorylation |
B | 0016311 | biological_process | dephosphorylation |
D | 0004725 | molecular_function | protein tyrosine phosphatase activity |
D | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
D | 0006470 | biological_process | protein dephosphorylation |
D | 0016311 | biological_process | dephosphorylation |
G | 0004725 | molecular_function | protein tyrosine phosphatase activity |
G | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
G | 0006470 | biological_process | protein dephosphorylation |
G | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
Chain | Residue |
B | TYR62 |
B | CYS233 |
B | GLY234 |
B | ARG235 |
B | GLN276 |
B | LYS63 |
B | ASP64 |
B | ASP197 |
B | ARG198 |
B | SER229 |
B | SER230 |
B | ALA231 |
B | GLY232 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
Chain | Residue |
D | TYR62 |
D | LYS63 |
D | ASP64 |
D | ARG140 |
D | ASP197 |
D | ARG198 |
D | SER229 |
D | SER230 |
D | ALA231 |
D | GLY232 |
D | CYS233 |
D | GLY234 |
D | ARG235 |
D | GLN276 |
D | HOH301 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
Chain | Residue |
A | TYR62 |
A | LYS63 |
A | ASP64 |
A | ASP197 |
A | ARG198 |
A | SER229 |
A | SER230 |
A | ALA231 |
A | GLY232 |
A | CYS233 |
A | GLY234 |
A | ARG235 |
A | GLN276 |
site_id | AC4 |
Number of Residues | 17 |
Details | BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 |
Chain | Residue |
G | TYR62 |
G | LYS63 |
G | ASP64 |
G | VAL65 |
G | ARG138 |
G | ASP197 |
G | ARG198 |
G | SER229 |
G | SER230 |
G | ALA231 |
G | GLY232 |
G | CYS233 |
G | GLY234 |
G | ARG235 |
G | GLN276 |
G | HOH301 |
H | HOH201 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:27134172 |
Chain | Residue | Details |
F | PTR112 | |
C | PTR112 | |
E | PTR112 | |
H | PTR112 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ASP197 | |
G | ASP197 | |
G | SER229 | |
G | GLN276 | |
A | SER229 | |
A | GLN276 | |
B | ASP197 | |
B | SER229 | |
B | GLN276 | |
D | ASP197 | |
D | SER229 | |
D | GLN276 |