3ZM2

Catalytic domain of human SHP2

Summary for 3ZM2

Entry DOI	10.2210/pdb3zm2/pdb
Related	3ZM0 3ZM1 3ZM3
Descriptor	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 (2 entities in total)
Functional Keywords	hydrolase, ptp1b
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q06124
Total number of polymer chains	1
Total formula weight	33109.61
Authors	Bohm, K.,Schuetz, A.,Roske, Y.,Heinemann, U. (deposition date: 2013-02-04, release date: 2014-04-23, Last modification date: 2023-12-20)
Primary citation	Grosskopf, S.,Eckert, C.,Arkona, C.,Radetzki, S.,Bohm, K.,Heinemann, U.,Wolber, G.,Von Kries, J.,Birchmeier, W.,Rademann, J. Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10:815-, 2015 Cited by PubMed: 25877780 DOI: 10.1002/CMDC.201500015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation