3ZM2
Catalytic domain of human SHP2
Summary for 3ZM2
Entry DOI | 10.2210/pdb3zm2/pdb |
Related | 3ZM0 3ZM1 3ZM3 |
Descriptor | TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 (2 entities in total) |
Functional Keywords | hydrolase, ptp1b |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 33109.61 |
Authors | Bohm, K.,Schuetz, A.,Roske, Y.,Heinemann, U. (deposition date: 2013-02-04, release date: 2014-04-23, Last modification date: 2023-12-20) |
Primary citation | Grosskopf, S.,Eckert, C.,Arkona, C.,Radetzki, S.,Bohm, K.,Heinemann, U.,Wolber, G.,Von Kries, J.,Birchmeier, W.,Rademann, J. Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10:815-, 2015 Cited by PubMed: 25877780DOI: 10.1002/CMDC.201500015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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