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PDB: 663 results
4LZ8
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BU of 4lz8 by Molmil
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide, ...
Authors:Pandit, J.
Deposit date:2013-07-31
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
J.Med.Chem., 56, 2013
4IY5
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BU of 4iy5 by Molmil
Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution
Descriptor: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ...
Authors:Krintel, C, Frydenvang, K, Harpsoe, K, Gajhede, M, Kastrup, J.S.
Deposit date:2013-01-28
Release date:2013-10-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Acta Crystallogr.,Sect.D, 69, 2013
3H06
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BU of 3h06 by Molmil
Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282
Descriptor: 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid, Glutamate receptor 2
Authors:Ahmed, A.H, Oswald, R.E.
Deposit date:2009-04-08
Release date:2009-05-05
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Biochemistry, 48, 2009
3H03
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BU of 3h03 by Molmil
Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277
Descriptor: 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine, Glutamate receptor 2, ZINC ION
Authors:Ahmed, A.H, Oswald, R.E.
Deposit date:2009-04-08
Release date:2009-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Biochemistry, 48, 2009
3H6W
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BU of 3h6w by Molmil
Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution
Descriptor: (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ...
Authors:Hald, H, Gajhede, M, Kastrup, J.S.
Deposit date:2009-04-24
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
J.Mol.Biol., 391, 2009
7QHB
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BU of 7qhb by Molmil
Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ...
Authors:Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H.
Deposit date:2021-12-11
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
3H6U
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BU of 3h6u by Molmil
Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution
Descriptor: (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CITRATE ANION, GLUTAMIC ACID, ...
Authors:Hald, H, Gajhede, M, Kastrup, J.S.
Deposit date:2009-04-24
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
J.Mol.Biol., 391, 2009
3IL1
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BU of 3il1 by Molmil
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21
Descriptor: (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Ahmed, A.H, Ptak, C.P, Oswald, R.E.
Deposit date:2009-08-06
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3ILT
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BU of 3ilt by Molmil
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide
Descriptor: 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Ahmed, A.H, Ptak, C.P, Oswald, R.E.
Deposit date:2009-08-07
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.107 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3IK6
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BU of 3ik6 by Molmil
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide
Descriptor: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Ptak, C.P, Ahmed, A.H, Oswald, R.E.
Deposit date:2009-08-05
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3IJO
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BU of 3ijo by Molmil
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide
Descriptor: (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Ptak, C.P, Ahmed, A.H, Oswald, R.E.
Deposit date:2009-08-04
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3IJX
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BU of 3ijx by Molmil
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide
Descriptor: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Ptak, C.P, Ahmed, A.H, Oswald, R.E.
Deposit date:2009-08-05
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.881 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
7QHH
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BU of 7qhh by Molmil
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ...
Authors:Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H.
Deposit date:2021-12-12
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
3ILU
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BU of 3ilu by Molmil
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide
Descriptor: 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Ahmed, A.H, Ptak, C.P, Oswald, R.E.
Deposit date:2009-08-07
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
7RZ7
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BU of 7rz7 by Molmil
Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist Quisqualate
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Klykov, O.V, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RZ4
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BU of 7rz4 by Molmil
Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2, ...
Authors:Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RZ8
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BU of 7rz8 by Molmil
Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist quisqualate
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Glutamate receptor 2
Authors:Klykov, O.V, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RZ5
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BU of 7rz5 by Molmil
Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RZ9
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BU of 7rz9 by Molmil
Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L in the apo state
Descriptor: Glutamate receptor 2
Authors:Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.15 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RZA
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BU of 7rza by Molmil
Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.26 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RYY
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BU of 7ryy by Molmil
Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2
Authors:Klykov, O.V, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-26
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RZ6
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BU of 7rz6 by Molmil
Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2
Authors:Klykov, O.V, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RYZ
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BU of 7ryz by Molmil
Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-26
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.15 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7SAB
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BU of 7sab by Molmil
Phencyclidine-bound GluN1a-GluN2B NMDA receptors
Descriptor: 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2021-09-22
Release date:2022-07-20
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
7SAD
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BU of 7sad by Molmil
Memantine-bound GluN1a-GluN2B NMDA receptors
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2021-09-22
Release date:2022-07-20
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022

221051

數據於2024-06-12公開中

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