5VIH

Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC

Replaces:  5DE4

Summary for 5VIH

• Entry DOI: 10.2210/pdb5vih/pdb
• Related: 5VII 5VIJ
• Descriptor: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2A, GLYCINE, ... (6 entities in total)
• Functional Keywords: nmda receptor, antagonist, transport protein, receptor
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 65599.77

Authors

Mou, T.-C.,Conti, P.,Pinto, A.,Tamborini, L.,Sprang, S.R.,Hansen, K.B. (deposition date: 2017-04-16, release date: 2017-04-26, Last modification date: 2023-10-04)

• Primary citation: Lind, G.E.,Mou, T.C.,Tamborini, L.,Pomper, M.G.,De Micheli, C.,Conti, P.,Pinto, A.,Hansen, K.B.; Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.; Proc. Natl. Acad. Sci. U.S.A., 114:E6942-E6951, 2017; PubMed: 28760974; DOI: 10.1073/pnas.1707752114

Experimental method

X-RAY DIFFRACTION (2.4 Å)