Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5TPA

Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500)

Summary for 5TPA
Entry DOI10.2210/pdb5tpa/pdb
Related5TP9
DescriptorGlutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1, GLUTAMIC ACID, ... (6 entities in total)
Functional Keywordsnmda receptor, glutamate, glycine, calcium channel, membrane, transport protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane; Multi-pass membrane protein: Q12879 Q05586
Total number of polymer chains2
Total formula weight65922.49
Authors
Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2016-10-20, release date: 2016-11-30, Last modification date: 2017-02-01)
Primary citationVillemure, E.,Volgraf, M.,Jiang, Y.,Wu, G.,Ly, C.Q.,Yuen, P.W.,Lu, A.,Luo, X.,Liu, M.,Zhang, S.,Lupardus, P.J.,Wallweber, H.J.,Liederer, B.M.,Deshmukh, G.,Plise, E.,Tay, S.,Wang, T.M.,Hanson, J.E.,Hackos, D.H.,Scearce-Levie, K.,Schwarz, J.B.,Sellers, B.D.
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8:84-89, 2017
Cited by
PubMed: 28105280
DOI: 10.1021/acsmedchemlett.6b00388
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.48 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon