5TPA
Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue GLU A 301 |
| Chain | Residue |
| A | HIS87 |
| A | HOH408 |
| A | HOH416 |
| A | HOH428 |
| A | SER113 |
| A | THR115 |
| A | ARG120 |
| A | GLY171 |
| A | SER172 |
| A | THR173 |
| A | TYR213 |
| A | ASP214 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue 7H2 A 302 |
| Chain | Residue |
| A | ILE116 |
| A | PRO129 |
| A | PHE130 |
| A | VAL131 |
| A | GLU132 |
| A | THR242 |
| A | GLY243 |
| A | VAL266 |
| B | ILE128 |
| B | LYS140 |
| B | PRO141 |
| B | TYR144 |
| B | LEU270 |
| B | HIS273 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GLY B 301 |
| Chain | Residue |
| B | PHE93 |
| B | PRO125 |
| B | LEU126 |
| B | THR127 |
| B | ARG132 |
| B | SER180 |
| B | SER181 |
| B | ASP225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA |
| Chain | Residue | Details |
| B | LYS104 | |
| B | MET111 | |
| B | ILE160 | |
| B | TYR204 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | THR28 | |
| B | THR59 | |
| B | MET79 | |
| B | GLY243 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN45 | |
| A | ASN46 | |
| A | ASN170 |
