6TXR
 
 | | Structural insights into cubane-modified aptamer recognition of a malaria biomarker | | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ... | | Authors: | Cheung, Y, Roethlisberger, P, Mechaly, A, Weber, P, Wong, A, Lo, Y, Haouz, A, Savage, P, Hollenstein, M, Tanner, J. | | Deposit date: | 2020-01-14 | | Release date: | 2020-07-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2V7P
 | | Crystal structure of lactate dehydrogenase from Thermus Thermophilus HB8 (Holo form) | | Descriptor: | L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID | | Authors: | Coquelle, N, Fioravanti, E, Weik, M, Vellieux, F. | | Deposit date: | 2007-07-31 | | Release date: | 2007-09-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments.
J. Mol. Biol., 374, 2007
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2V6M
 | | Crystal structure of lactate dehydrogenase from Thermus Thermophilus HB8 (Apo form) | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, L-LACTATE DEHYDROGENASE | | Authors: | Coquelle, N, Fioravanti, E, Weik, M, Vellieux, F. | | Deposit date: | 2007-07-19 | | Release date: | 2007-09-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments.
J. Mol. Biol., 374, 2007
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2V65
 | | Apo LDH from the psychrophile C. gunnari | | Descriptor: | L-LACTATE DEHYDROGENASE A CHAIN | | Authors: | Coquelle, N, Madern, D, Vellieux, F. | | Deposit date: | 2007-07-13 | | Release date: | 2007-09-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments.
J.Mol.Biol., 374, 2007
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2V6B
 | | Crystal structure of lactate dehydrogenase from Deinococcus Radiodurans (apo form) | | Descriptor: | L-LACTATE DEHYDROGENASE | | Authors: | Coquelle, N, Fioravanti, E, Weik, M, Vellieux, F. | | Deposit date: | 2007-07-16 | | Release date: | 2007-09-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments.
J. Mol. Biol., 374, 2007
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3NEP
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5MDH
 | | CRYSTAL STRUCTURE OF TERNARY COMPLEX OF PORCINE CYTOPLASMIC MALATE DEHYDROGENASE ALPHA-KETOMALONATE AND TNAD AT 2.4 ANGSTROMS RESOLUTION | | Descriptor: | ALPHA-KETOMALONIC ACID, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Chapman, A.D.M, Cortes, A, Dafforn, T.R, Clarke, A.R, Brady, R.L. | | Deposit date: | 1998-10-08 | | Release date: | 1999-05-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD.
J.Mol.Biol., 285, 1999
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5NQB
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8FW6
 | | Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336 | | Descriptor: | (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | Authors: | Lowther, W.T, Gumpena, R. | | Deposit date: | 2023-01-20 | | Release date: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Human Lactate Dehydrogenase A in complex with inhibitor CHK-336
To Be Published
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5NFR
 | | Crystal structure of malate dehydrogenase from Plasmodium falciparum (PfMDH) | | Descriptor: | CITRIC ACID, Malate dehydrogenase | | Authors: | Lunev, S, Romero, A.R, Batista, F.A, Wrenger, C, Groves, M.R. | | Deposit date: | 2017-03-15 | | Release date: | 2018-01-31 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro.
PLoS ONE, 13, 2018
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5NQQ
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3P7M
 | | Structure of putative lactate dehydrogenase from Francisella tularensis subsp. tularensis SCHU S4 | | Descriptor: | Malate dehydrogenase, PHOSPHATE ION | | Authors: | Osinski, T, Cymborowski, M, Zimmerman, M.D, Gordon, E, Grimshaw, S, Skarina, T, Chruszcz, M, Savchenko, A, Anderson, W, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2010-10-12 | | Release date: | 2010-10-20 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of putative lactate dehydrogenase from Francisella tularensis subsp. tularensis SCHU S4
To be Published
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5NUF
 | | Cytosolic Malate Dehydrogenase 1 | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Young, D, Messens, J, Huang, J, Reichheld, J.-P. | | Deposit date: | 2017-04-29 | | Release date: | 2018-01-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
J. Exp. Bot., 69, 2018
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5NUE
 | | Cytosolic Malate Dehydrogenase 1 (peroxide-treated) | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-ETHOXYETHANOL, ... | | Authors: | Young, D, Messens, J, Huang, J, Reichheld, J.-P. | | Deposit date: | 2017-04-29 | | Release date: | 2018-02-28 | | Last modified: | 2018-07-04 | | Method: | X-RAY DIFFRACTION (1.35000277 Å) | | Cite: | Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
J. Exp. Bot., 69, 2018
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3OM9
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8GH2
 | | Structure of Trypanosoma (MDH)4-(Pex5)2, close conformation | | Descriptor: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | Authors: | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | Deposit date: | 2023-03-09 | | Release date: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Structure of Trypanosoma (MDH)4-(Pex5)2, close conformation
To Be Published
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8GGH
 | | Structure of Trypanosoma (MDH)4-PEX5, distal conformation | | Descriptor: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | Authors: | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | Deposit date: | 2023-03-08 | | Release date: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structure of Trypanosoma (MDH)4-PEX5, distal conformation
To Be Published
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8GI0
 | | Structure of Trypanosoma docking complex | | Descriptor: | Peroxisomal membrane protein PEX14, Peroxisome targeting signal 1 receptor, malate dehydrogenase | | Authors: | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | Deposit date: | 2023-03-13 | | Release date: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of Trypanosoma docking complex
To Be Published
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8GH3
 | | Structure of Trypanosoma (MDH)4-(Pex5)2, distal conformation | | Descriptor: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | Authors: | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | Deposit date: | 2023-03-09 | | Release date: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structure of Trypanosoma (MDH)4-(Pex5)2, distal conformation
To Be Published
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8GGD
 | | Structure of Trypanosoma (MDH)4-Pex5, close conformation | | Descriptor: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | Authors: | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | Deposit date: | 2023-03-08 | | Release date: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | Structure of Trypanosoma (MDH)4-Pex5, close conformation
To Be Published
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3PQE
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3PQF
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3PQD
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5IXY
 | | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one | | Descriptor: | (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Chen, Z, Eigenbrot, C. | | Deposit date: | 2016-03-23 | | Release date: | 2016-09-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
Acs Med.Chem.Lett., 7, 2016
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5IXS
 | | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one | | Descriptor: | (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | Authors: | Ultsch, M, Eigenbrot, C. | | Deposit date: | 2016-03-23 | | Release date: | 2016-09-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
Acs Med.Chem.Lett., 7, 2016
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