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PDB: 8 results
6W6O
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BU of 6w6o by Molmil
NaChBac-Nav1.7VSDII chimera and HWTX-IV complex
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Huwentoxin-IV, NaChBac-Nav1.7VSDII chimera
Authors:Yan, N, Gao, S.
Deposit date:2020-03-17
Release date:2020-06-24
Last modified:2021-01-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc.
Proc.Natl.Acad.Sci.USA, 117, 2020
7K48
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BU of 7k48 by Molmil
Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV
Descriptor: Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a
Authors:Wisedchaisri, G, Tonggu, L, Gamal El-Din, T.M, McCord, E, Zheng, N, Catterall, W.A.
Deposit date:2020-09-15
Release date:2020-12-02
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin.
Mol.Cell, 81, 2021
1MB6
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BU of 1mb6 by Molmil
Three dimensional solution structure of huwentoxin-IV by 2D 1H-NMR
Descriptor: huwentoxin-iv
Authors:Peng, K, Shu, Q, Liang, S.P.
Deposit date:2002-08-02
Release date:2002-08-21
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena
J.Biol.Chem., 277, 2002
2M50
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Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).
Descriptor: Mu-theraphotoxin-Hh2a
Authors:Gibbs, A, Minassian, N, Flinspach, M, Wickenden, A.
Deposit date:2013-02-12
Release date:2013-06-19
Last modified:2023-11-29
Method:SOLUTION NMR
Cite:Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a).
J.Biol.Chem., 288, 2013
2M4X
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BU of 2m4x by Molmil
Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).
Descriptor: Mu-theraphotoxin-Hh2a
Authors:Gibbs, A, Flinspach, M.
Deposit date:2013-02-11
Release date:2013-06-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a).
J.Biol.Chem., 288, 2013
2M4Z
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BU of 2m4z by Molmil
Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).
Descriptor: Mu-theraphotoxin-Hh2a
Authors:Gibbs, A.
Deposit date:2013-02-12
Release date:2013-06-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a).
J.Biol.Chem., 288, 2013
5T3M
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Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7
Descriptor: Mu-theraphotoxin-Hs2a
Authors:Rahnama, S, Sharma, G, Mobli, M.
Deposit date:2016-08-25
Release date:2017-09-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
PLoS ONE, 12, 2017
5TLR
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BU of 5tlr by Molmil
Solution NMR structure of gHwTx-IV
Descriptor: Mu-theraphotoxin-Hs2a
Authors:Agwa, A.J, Schroeder, C.I.
Deposit date:2016-10-11
Release date:2017-02-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.
Biochim. Biophys. Acta, 1859, 2017

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數據於2024-07-10公開中

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