6MSE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mse by Molmil](/molmil-images/mine/6mse) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-11-21 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
|
|
3JVZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3jvz by Molmil](/molmil-images/mine/3jvz) | E2~Ubiquitin-HECT | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | Authors: | Souphron, J, Kamadurai, H.B, Schulman, B.A. | Deposit date: | 2009-09-17 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
|
|
8J1P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j1p by Molmil](/molmil-images/mine/8j1p) | Cryo-EM structure of Ufd4 in complex with K29/48 triUb | Descriptor: | Ubiquitin, Ubiquitin fusion degradation protein 4 | Authors: | Ai, H.S, Mao, J.X, Wu, X.W, Pan, M, Liu, L. | Deposit date: | 2023-04-13 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Structural Insights into the Molecular Mechanism of Ufd4-catalyzed Elongation of K48-linked Ubiquitin Chain through Lys29 Linkage To Be Published
|
|
5JTV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jtv by Molmil](/molmil-images/mine/5jtv) | USP7CD-UBL45 in complex with Ubiquitin | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Murray, J.M, Rouge, L. | Deposit date: | 2016-05-09 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.312 Å) | Cite: | Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation. Structure, 24, 2016
|
|
5JTJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jtj by Molmil](/molmil-images/mine/5jtj) | USP7CD-CTP in complex with Ubiquitin | Descriptor: | CALCIUM ION, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7,Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Murray, J.M, Rouge, L. | Deposit date: | 2016-05-09 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.321 Å) | Cite: | Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation. Structure, 24, 2016
|
|
7MEX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mex by Molmil](/molmil-images/mine/7mex) | Structure of yeast Ubr1 in complex with Ubc2 and N-degron | Descriptor: | E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-04-08 | Release date: | 2021-11-24 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
|
|
5CVN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cvn by Molmil](/molmil-images/mine/5cvn) | WDR48 (2-580):USP46~ubiquitin ternary complex | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | Authors: | Harris, S.F, Yin, J. | Deposit date: | 2015-07-27 | Release date: | 2015-10-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure, 23, 2015
|
|
6VEN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ven by Molmil](/molmil-images/mine/6ven) | |
7YQK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yqk by Molmil](/molmil-images/mine/7yqk) | cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1 | Descriptor: | DNA (145-MER), Histone H2AX, Histone H2B, ... | Authors: | Ai, H.S, GuoChao, C, Qingyue, G, Ze-Bin, T, Zhiheng, D, Xin, L, Fan, Y, Ziyu, X, Jia-Bin, L, Changlin, T, Liu, L. | Deposit date: | 2022-08-07 | Release date: | 2022-08-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Chemical Synthesis of Post-Translationally Modified H2AX Reveals Redundancy in Interplay between Histone Phosphorylation, Ubiquitination, and Methylation on the Binding of 53BP1 with Nucleosomes. J.Am.Chem.Soc., 144, 2022
|
|
8OFF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8off by Molmil](/molmil-images/mine/8off) | Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1) | Descriptor: | BRCA1 associated RING domain 1, DNA (142-MER), Histone H2A type 1, ... | Authors: | Foglizzo, M, Burdett, H, Wilson, M.D, Zeqiraj, E. | Deposit date: | 2023-03-15 | Release date: | 2023-10-11 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes. Nucleic Acids Res., 51, 2023
|
|
7W3C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w3c by Molmil](/molmil-images/mine/7w3c) | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED0_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
|
|
5AF6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5af6 by Molmil](/molmil-images/mine/5af6) | Structure of Lys33-linked diUb bound to Trabid NZF1 | Descriptor: | TRABID, UBIQUITIN, ZINC ION | Authors: | Michel, M.A, Elliott, P.R, Swatek, K.N, Simicek, M, Pruneda, J.N, Wagstaff, J.L, Freund, S.M.V, Komander, D. | Deposit date: | 2015-01-19 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin. Mol.Cell, 58, 2015
|
|
8PJN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pjn by Molmil](/molmil-images/mine/8pjn) | Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin | Descriptor: | E3 ubiquitin-protein transferase MAEA, E3 ubiquitin-protein transferase RMND5A, Ubiquitin, ... | Authors: | Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A. | Deposit date: | 2023-06-23 | Release date: | 2024-01-03 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Mol.Cell, 84, 2024
|
|
3OJ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3oj4 by Molmil](/molmil-images/mine/3oj4) | |
8G6Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g6q by Molmil](/molmil-images/mine/8g6q) | |
5VNZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vnz by Molmil](/molmil-images/mine/5vnz) | Structure of a TRAF6-Ubc13~Ub complex | Descriptor: | TNF receptor-associated factor 6, Ubiquitin, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2017-05-01 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
|
|
8R5H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8r5h by Molmil](/molmil-images/mine/8r5h) | Ubiquitin ligation to neosubstrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-VHL-MZ1 with trapped UBE2R2~donor UB-BRD4 BD2 | Descriptor: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 5-azanylpentan-2-one, Bromodomain-containing protein 4, ... | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | Deposit date: | 2023-11-16 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
|
|
8G6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g6s by Molmil](/molmil-images/mine/8g6s) | |
5EDV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5edv by Molmil](/molmil-images/mine/5edv) | Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex | Descriptor: | E3 ubiquitin-protein ligase RNF31, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ... | Authors: | Lechtenberg, B.C, Mace, P.D, Sanishvili, R, Riedl, S.J. | Deposit date: | 2015-10-22 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation. Nature, 529, 2016
|
|
5H7S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h7s by Molmil](/molmil-images/mine/5h7s) | |
6O96
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o96 by Molmil](/molmil-images/mine/6o96) | Dot1L bound to the H2BK120 Ubiquitinated nucleosome | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Valencia-Sanchez, M.I, De Ioannes, P.E, Miao, W, Vasilyev, N, Chen, R, Nudler, E, Armache, J.-P, Armache, K.-J. | Deposit date: | 2019-03-13 | Release date: | 2019-04-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination. Mol.Cell, 74, 2019
|
|
6UH5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6uh5 by Molmil](/molmil-images/mine/6uh5) | Structural basis of COMPASS eCM recognition of the H2Bub nucleosome | Descriptor: | Bre2, DNA (146-MER), H3 N-terminus, ... | Authors: | Hsu, P.L, Shi, H, Zheng, N. | Deposit date: | 2019-09-26 | Release date: | 2019-11-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS. Mol.Cell, 76, 2019
|
|
7W3M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w3m by Molmil](/molmil-images/mine/7w3m) | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD5_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
|
|
7W3I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w3i by Molmil](/molmil-images/mine/7w3i) | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
|
|
6VAE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vae by Molmil](/molmil-images/mine/6vae) | |