6RHY
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6YHF
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![BU of 6yhf by Molmil](/molmil-images/mine/6yhf) | Solution NMR Structure of APP TMD | Descriptor: | Amyloid-beta precursor protein | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-29 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHO
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![BU of 6yho by Molmil](/molmil-images/mine/6yho) | Solution NMR Structure of APP G38P mutant TM | Descriptor: | Amyloid-beta precursor protein G38P mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHP
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![BU of 6yhp by Molmil](/molmil-images/mine/6yhp) | Solution NMR Structure of APP V44M mutant TMD | Descriptor: | Amyloid-beta precursor protein V44M mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHX
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![BU of 6yhx by Molmil](/molmil-images/mine/6yhx) | Solution NMR Structure of APP I45T mutant TMD | Descriptor: | Amyloid-beta precursor protein I45T mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-31 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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2MXU
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![BU of 2mxu by Molmil](/molmil-images/mine/2mxu) | 42-Residue Beta Amyloid Fibril | Descriptor: | Amyloid beta A4 protein | Authors: | Xiao, Y, Ma, B, McElheny, D, Parthasarathy, S, Long, F, Hoshi, M, Nussinov, R, Ishii, Y. | Deposit date: | 2015-01-14 | Release date: | 2015-05-06 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | A beta (1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease. Nat.Struct.Mol.Biol., 22, 2015
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2MPZ
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6YHI
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![BU of 6yhi by Molmil](/molmil-images/mine/6yhi) | Solution NMR Structure of APP G38L mutant TMD | Descriptor: | Amyloid-beta precursor protein G38L mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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1AMB
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6SZF
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![BU of 6szf by Molmil](/molmil-images/mine/6szf) | Solution structure of the amyloid beta-peptide (1-42) | Descriptor: | Amyloid-beta precursor protein | Authors: | Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M. | Deposit date: | 2019-10-02 | Release date: | 2020-10-14 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study. Pharmaceuticals, 14, 2021
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1Z0Q
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![BU of 1z0q by Molmil](/molmil-images/mine/1z0q) | Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42) | Descriptor: | Alzheimer's disease amyloid | Authors: | Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D. | Deposit date: | 2005-03-02 | Release date: | 2006-05-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding Chembiochem, 7, 2006
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1BA4
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![BU of 1ba4 by Molmil](/molmil-images/mine/1ba4) | THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES | Descriptor: | AMYLOID BETA-PEPTIDE | Authors: | Coles, M, Bicknell, W, Watson, A.A, Fairlie, D.P, Craik, D.J. | Deposit date: | 1998-04-07 | Release date: | 1998-06-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is? Biochemistry, 37, 1998
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7B3K
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![BU of 7b3k by Molmil](/molmil-images/mine/7b3k) | Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55) | Descriptor: | D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein | Authors: | Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
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1ZE7
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![BU of 1ze7 by Molmil](/molmil-images/mine/1ze7) | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in water solution at pH 6.5 | Descriptor: | 16-mer from Alzheimer's disease amyloid Protein | Authors: | Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S. | Deposit date: | 2005-04-18 | Release date: | 2005-05-03 | Last modified: | 2013-10-09 | Method: | SOLUTION NMR | Cite: | Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging. J.Biol.Chem., 281, 2006
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1ZE9
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![BU of 1ze9 by Molmil](/molmil-images/mine/1ze9) | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide complexed with a zinc (II) cation | Descriptor: | 16-mer from Alzheimer's disease amyloid Protein, ZINC ION | Authors: | Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S. | Deposit date: | 2005-04-18 | Release date: | 2005-05-03 | Last modified: | 2013-10-09 | Method: | SOLUTION NMR | Cite: | Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging. J.Biol.Chem., 281, 2006
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1AML
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8B9R
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![BU of 8b9r by Molmil](/molmil-images/mine/8b9r) | Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease | Descriptor: | Amyloid-beta A4 protein, COPPER (II) ION | Authors: | Abelein, A, Ciofi-Baffoni, S, Morman, C, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H. | Deposit date: | 2022-10-06 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease. Jacs Au, 2, 2022
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6TI5
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![BU of 6ti5 by Molmil](/molmil-images/mine/6ti5) | A New Structural Model of Abeta(1-40) Fibrils | Descriptor: | Amyloid-beta precursor protein | Authors: | Bertini, I, Gonnelli, L, Luchinat, C, Mao, J, Nesi, A. | Deposit date: | 2019-11-21 | Release date: | 2020-07-22 | Last modified: | 2024-06-19 | Method: | SOLID-STATE NMR | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
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6TI6
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![BU of 6ti6 by Molmil](/molmil-images/mine/6ti6) | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | Descriptor: | Amyloid-beta precursor protein | Authors: | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | Deposit date: | 2019-11-21 | Release date: | 2020-07-22 | Last modified: | 2024-06-19 | Method: | SOLID-STATE NMR | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
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1BJB
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![BU of 1bjb by Molmil](/molmil-images/mine/1bjb) | SOLUTION NMR STRUCTURE OF AMYLOID BETA[E16], RESIDUES 1-28, 14 STRUCTURES | Descriptor: | AMYLOID BETA-PEPTIDE | Authors: | Poulsen, S.-A, Watson, A.A, Craik, D.J. | Deposit date: | 1998-06-23 | Release date: | 1998-11-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F) J.Struct.Biol., 130, 2000
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1BJC
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![BU of 1bjc by Molmil](/molmil-images/mine/1bjc) | SOLUTION NMR STRUCTURE OF AMYLOID BETA[F16], RESIDUES 1-28, 15 STRUCTURES | Descriptor: | AMYLOID BETA-PEPTIDE | Authors: | Poulsen, S.-A, Watson, A.A, Craik, D.J. | Deposit date: | 1998-06-23 | Release date: | 1998-11-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F) J.Struct.Biol., 130, 2000
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6TI7
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![BU of 6ti7 by Molmil](/molmil-images/mine/6ti7) | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | Descriptor: | Amyloid-beta precursor protein | Authors: | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | Deposit date: | 2019-11-21 | Release date: | 2020-07-22 | Last modified: | 2024-06-19 | Method: | SOLID-STATE NMR | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
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1BA6
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1OWT
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![BU of 1owt by Molmil](/molmil-images/mine/1owt) | Structure of the Alzheimer's disease amyloid precursor protein copper binding domain | Descriptor: | Amyloid beta A4 protein | Authors: | Barnham, K.J, McKinstry, W.J, Multhaup, G, Galatis, D, Morton, C.J, Curtain, C.C, Williamson, N.A, White, A.R, Hinds, M.G, Norton, R.S, Beyreuther, K, Masters, C.L, Parker, M.W, Cappai, R. | Deposit date: | 2003-03-30 | Release date: | 2003-05-13 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain. A REGULATOR OF NEURONAL COPPER HOMEOSTASIS. J.Biol.Chem., 278, 2003
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2OTK
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