2OTK

Structure of Alzheimer Ab peptide in complex with an engineered binding protein

Summary for 2OTK

• Entry DOI: 10.2210/pdb2otk/pdb
• Descriptor: Amyloid beta A4 protein, ZAb3 Affibody dimer (2 entities in total)
• Functional Keywords: protein-peptide complex, beta-hairpin, intermolecular beta-sheet, de novo protein, peptide binding protein
• Biological source: engineered binding protein; More
• Total number of polymer chains: 3
• Total formula weight: 19967.09

Authors

Hoyer, W.,Hard, T. (deposition date: 2007-02-08, release date: 2008-02-12, Last modification date: 2019-12-04)

• Primary citation: Hoyer, W.,Gronwall, C.,Jonsson, A.,Stahl, S.,Hard, T.; Stabilization of a beta-hairpin in monomeric Alzheimer's amyloid-beta peptide inhibits amyloid formation.; Proc.Natl.Acad.Sci.Usa, 105:5099-5104, 2008; PubMed: 18375754; DOI: 10.1073/pnas.0711731105

Experimental method

SOLUTION NMR