4HDD
| Domain swapping in the cytoplasmic domain of the Escherichia coli rhomboid protease | Descriptor: | ACETATE ION, Rhomboid protease GlpG | Authors: | Lazareno-Saez, C, Arutyunova, E, Coquelle, N, Lemieux, M.J. | Deposit date: | 2012-10-02 | Release date: | 2013-02-06 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Domain swapping in the cytoplasmic domain of the Escherichia coli rhomboid protease. J.Mol.Biol., 425, 2013
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2XOV
| Crystal Structure of E.coli rhomboid protease GlpG, native enzyme | Descriptor: | GLYCEROL, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside | Authors: | Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M. | Deposit date: | 2010-08-24 | Release date: | 2010-10-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The structural basis for catalysis and substrate specificity of a rhomboid protease. EMBO J., 29, 2010
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2XTV
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3B44
| Crystal structure of GlpG W136A mutant | Descriptor: | glpG, nonyl beta-D-glucopyranoside | Authors: | Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. | Deposit date: | 2007-10-23 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
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5MTF
| A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases | Descriptor: | CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ... | Authors: | Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K. | Deposit date: | 2017-01-09 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
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2XTU
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3B45
| Crystal structure of GlpG at 1.9A resolution | Descriptor: | glpG, nonyl beta-D-glucopyranoside | Authors: | Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. | Deposit date: | 2007-10-23 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
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5MT8
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5MT7
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2XOW
| Structure of GlpG in complex with a mechanism-based isocoumarin inhibitor | Descriptor: | 5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC ACID, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside | Authors: | Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M. | Deposit date: | 2010-08-24 | Release date: | 2010-10-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The Structural Basis for Catalysis and Substrate Specificity of a Rhomboid Protease Embo J., 29, 2010
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2IC8
| Crystal structure of GlpG | Descriptor: | Protein glpG, nonyl beta-D-glucopyranoside | Authors: | Ha, Y. | Deposit date: | 2006-09-12 | Release date: | 2006-10-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of a rhomboid family intramembrane protease. Nature, 444, 2006
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5MT6
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3ZMI
| Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 | Descriptor: | RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside, phenyl N-[(1R)-3-oxidanylidene-1-phenyl-propyl]carbamate | Authors: | Vinothkumar, K.R, Pierrat, O.A, Large, J.M, Freeman, M. | Deposit date: | 2013-02-11 | Release date: | 2013-05-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity. Structure, 21, 2013
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3ZEB
| A complex of GlpG with isocoumarin inhibitor covalently bonded to serine 201 and histidine 150 | Descriptor: | 2-phenylethyl 2-(4-azanyl-2-methanoyl-phenyl)ethanoate, CHLORIDE ION, RHOMBOID PROTEASE GLPG, ... | Authors: | Vinothkumar, K.R, voskya, O, Kuettler, E.V, Brouwer, A.J, Liskamp, R.M.J, Verhelst, S.H.L. | Deposit date: | 2012-12-04 | Release date: | 2013-02-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Activity-Based Probes for Rhomboid Proteases Discovered in a Mass Spectrometry-Based Assay. Proc.Natl.Acad.Sci.USA, 110, 2013
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2IRV
| Crystal structure of GlpG, a rhomboid intramembrane serine protease | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, DODECYL-BETA-D-MALTOSIDE, LAURYL DIMETHYLAMINE-N-OXIDE, ... | Authors: | Bibi, E, Fass, D, Ben-Shem, A. | Deposit date: | 2006-10-16 | Release date: | 2006-10-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc.Natl.Acad.Sci.Usa, 104, 2007
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6XRO
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3ZMJ
| Structure of E.coli rhomboid protease GlpG in complex with monobactam L61 | Descriptor: | 2-methylpropyl N-[(1R)-3-oxidanylidene-1-phenyl-propyl]carbamate, CHLORIDE ION, RHOMBOID PROTEASE GLPG, ... | Authors: | Vinothkumar, K.R, Pierrat, O, Large, J.M, Freeman, M. | Deposit date: | 2013-02-11 | Release date: | 2013-05-22 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity. Structure, 21, 2013
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5F5B
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5F5G
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6PJ7
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6PJ4
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6VJ8
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6VJ9
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3TXT
| Crystal structure of GlpG in complex with inhibitor DFP | Descriptor: | DIISOPROPYL PHOSPHONATE, Rhomboid protease glpG | Authors: | Xue, Y, Ha, Y. | Deposit date: | 2011-09-23 | Release date: | 2011-12-07 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structure of rhomboid protease GlpG in complex with a mechanism-based inhibitor To be Published
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3ZMH
| Structure of E.coli rhomboid protease GlpG in complex with monobactam L62 | Descriptor: | CHLORIDE ION, CYCLOPENTYL 2-OXO-4-PHENYLAZETIDINE-1-CARBOXYLATE, RHOMBOID PROTEASE GLPG, ... | Authors: | Vinothkumar, K.R, Pierrat, O.A, Large, J.M, Freeman, M. | Deposit date: | 2013-02-11 | Release date: | 2013-05-22 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of rhomboid protease in complex with beta-lactam inhibitors defines the S2' cavity. Structure, 21, 2013
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