3ZEB

A complex of GlpG with isocoumarin inhibitor covalently bonded to serine 201 and histidine 150

Summary for 3ZEB

Entry DOI	10.2210/pdb3zeb/pdb
Descriptor	RHOMBOID PROTEASE GLPG, 2-phenylethyl 2-(4-azanyl-2-methanoyl-phenyl)ethanoate, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydrolase, intra-membrane protease, serine protease, acyl enzyme
Biological source	ESCHERICHIA COLI
Total number of polymer chains	1
Total formula weight	22064.77
Authors	Vinothkumar, K.R.,voskya, O.,Kuettler, E.V.,Brouwer, A.J.,Liskamp, R.M.J.,Verhelst, S.H.L. (deposition date: 2012-12-04, release date: 2013-02-13, Last modification date: 2023-12-20)
Primary citation	Vosyka, O.,Vinothkumar, K.R.,Wolf, E.V.,Brouwer, A.J.,Liskamp, R.M.J.,Verhelst, S.H.L. Activity-Based Probes for Rhomboid Proteases Discovered in a Mass Spectrometry-Based Assay. Proc.Natl.Acad.Sci.USA, 110:2472-, 2013 Cited by PubMed: 23359682 DOI: 10.1073/PNAS.1215076110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation