5F5B
Structure of E.Coli GlpG complexed with peptidic inhibitor Ac-VRMA-CHO
Summary for 5F5B
| Entry DOI | 10.2210/pdb5f5b/pdb |
| Related | 2IC8 2IRV 5F5D 5F5G 5F5J 5F5K |
| Descriptor | Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde (3 entities in total) |
| Functional Keywords | rhomboid, membrane protease, aldehyde inhibitor, hydrolase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Escherichia coli More |
| Cellular location | Cell inner membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein : A0A0J2E248 |
| Total number of polymer chains | 2 |
| Total formula weight | 24302.78 |
| Authors | Urban, S.,Cho, S.,Dickey, S.W. (deposition date: 2015-12-04, release date: 2016-02-17, Last modification date: 2023-11-15) |
| Primary citation | Cho, S.,Dickey, S.W.,Urban, S. Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61:329-340, 2016 Cited by PubMed: 26805573DOI: 10.1016/j.molcel.2015.12.022 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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